Scopus
🔓 Açık Erişim
Efficacy and safety of concomitant chemoradiotherapy with cisplatin and docetaxel in patients with locally advanced squamous cell head and neck cancers
Asian Pacific Journal of Cancer Prevention · Ocak 2013
Makale Bilgileri
DergiAsian Pacific Journal of Cancer Prevention
Yayın TarihiOcak 2013
Cilt / Sayfa14 · 2557-2561
Scopus ID2-s2.0-84880296848
Erişim🔓 Açık Erişim
Özet
Background: Chemoradiation (CRT) using cisplatin-based regimens has become the standard of care in the treatment of squamous cell head and neck cancers (SCHNC). The impact of taxanes as radiosensitizing agents with concurrent CRT regimens is unknown. We therefore retrospectively evaluated the efficacy and tolerability of a weekly cisplatin+docetaxel combination with CRT in locally advanced SCHNC. Methods: Sixty-six patients with locally advanced SCHNC (39.4% stage IV, 53% stage III, and 7.6% stage II) were assessed retrospectively. Total radiation dose to the PTV of gross disease (primary and/or node) was 70 Gy/35 fractions, 5 fractions per week. Minimum doses of 60 Gy and 50 Gy were administered to PTVs of elective high risk and low risk disease, respectively. Chemotherapy (CT) consisted of weekly cisplatin (20 mg/m2)+docetaxel (20 mg/m2) concurrently with RT. Results: The median age of the patients was 58 years (range, 32-77). Objective response rate was 83.3%. The 2-year progression-free survival (PFS) and overall survival (OS) were 75.7% and 78.3%, respectively. The most common grade 3 and 4 toxicities were mucositis (36.4%), nausea and vomiting (12.1%), neutropenia (4.5%). Conclusion: Weekly cisplatin and docetaxel concurrent with RT for locally advanced SCHNC was found tolerable with high efficacy.
Yazarlar (10)
1
Meltem Baykara
2
Süleyman Büyükberber
3
Banu Turgut Ozturk
ORCID: 0000-0003-0702-6951
4
Ugur Coskun
5
Diclehan Kilic Unsal
6
Umut Demirci
7
Faysal Dane
8
Muhammet Ali Kaplan
9
Huseyin Bora
10
Mustafa Benekli
Anahtar Kelimeler
Chemoradiotherapy
Cisplatin
Docetaxel
Safety
Squamous cell head and neck cancers
Kurumlar
Ataturk Training and Research Hospital
Izmir Turkey
Dicle University, Faculty of Medicine
Diyarbakir Turkey
Gazi University, Faculty of Medicine
Ankara Turkey
Marmara Üniversitesi
Istanbul Turkey
Sakarya Üniversitesi
Serdivan Turkey
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
Metrikler
10
Atıf
10
Yazar
5
Anahtar Kelime