Scopus
🔓 Açık Erişim
Non-Urothelial Bladder Cancer: Comparison of Clinicopathological and Prognostic Characteristics in Pure Adenocarcinoma and Non-Bilharzial Squamous Cell Carcinoma of the Bladder
Oncology Research and Treatment · Nisan 2018
Makale Bilgileri
DergiOncology Research and Treatment
Yayın TarihiNisan 2018
Cilt / Sayfa41 · 220-225
Scopus ID2-s2.0-85044358964
Erişim🔓 Açık Erişim
Özet
Objectives: The clinicopathological characteristics, treatment modalities, and effects on the prognosis of pure squamous cell carcinoma (SqCC) and adenocarcinoma (AC) were evaluated. Materials and Methods: 86 patients with pure SqCC and AC bladder cancer were evaluated retrospectively. Results: Of the 86 patients, 51 had SqCC and 35 had AC. No differences in clinicopathological characteristics were observed between patients with AC and SqCC, except for the prevalence of T4 disease (28.6% vs. 51.0%, respectively). In multivariate analysis, older age, stage IV disease, and Eastern Cooperative Oncology Group (ECOG) performance status (> 2) were predictive of a poor overall survival (OS). The median OS was significantly longer for stage I-III patients (82.9 months) treated with surgery ± chemotherapy (CT) ± radiotherapy (RT) than for those treated with transurethral resection ± CT ± RT (24.3 months) (P = 0.007). The median OS of patients with SqCC and AC who were given platinum-based CT for metastasis was 7.7 and 30.3 months, respectively. Conclusions: Advanced age, stage IV disease, and poor ECOG performance status were factors associated with a poor prognosis. Surgery ± CT ± RT resulted in significantly better OS, except in stage IV disease. Patients with metastatic AC had better response rates with platinum- based CT.
Yazarlar (17)
1
Gokmen Umut Erdem
ORCID: 0000-0002-3375-9465
2
Mutlu Dogan
3
Abdullah Sakin
4
Zeynep Oruc
ORCID: 0000-0002-7931-2941
5
Emel Yaman
6
Havva Yesil Cinkir
7
Mükremin Uysal
8
Oktay Bozkurt
9
Banu Turgut Ozturk
ORCID: 0000-0003-0702-6951
10
Aydin Aytekin
11
Melike Ozcelik
12
Aykut Bahceci
13
Umut Cakiroglu
14
Serdal Turhal
15
Suleyman Sahin
16
Dogan Uncu
17
Nurullah Zengin
Anahtar Kelimeler
Adenocarcinoma
Bladder cancer
Non-urothelial
Squamous cell carcinoma
Kurumlar
Afyon Kocatepe Üniversitesi Tıp Fakültesi
Afyonkarahisar Turkey
Anadolu Medical Center
Kocaeli Turkey
Ankara Numune Education and Research Hospital
Ankara Turkey
Ankara Oncology Education and Research Hospital
Ankara Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Dicle University, Faculty of Medicine
Diyarbakir Turkey
Diskapi Yildirim Beyazit Education and Training Hospital
Ankara Turkey
Erciyes Üniversitesi
Kayseri Turkey
Gazi Üniversitesi
Ankara Turkey
Kartal Education and Research Hospital
Istanbul Turkey
Kocaeli Derince Training and Research Hospital
Kocaeli Turkey
Mersin Üniversitesi
Mersin Turkey
Pamukkale Üniversitesi
Denizli Turkey
Saǧlik Bakanliǧi Okmeydani Eǧitim ve Araştirma Hastanesi
Okmeydani Turkey
Metrikler
5
Atıf
17
Yazar
4
Anahtar Kelime