Scopus
🔓 Açık Erişim
Prognostic factors of patients who received chemotherapy after cranial irradiation for non-small cell lung cancer with brain metastases: A retrospective analysis of multicenter study (Anatolian Society of Medical Oncology)
Journal of Cancer Research and Therapeutics · Nisan 2018
Makale Bilgileri
DergiJournal of Cancer Research and Therapeutics
Yayın TarihiNisan 2018
Cilt / Sayfa14 · 578-582
Scopus ID2-s2.0-85048665590
Erişim🔓 Açık Erişim
Özet
Purpose: Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third of patients with NSCLC will have brain metastases. Without effective treatment, the median survival is only 1 month. However, it is difficult to treat brain metastases with systemic chemotherapy since the agents have difficulty crossing the blood-brain barrier. Therefore, it is important to estimate the patient's survival prognosis. The aim of this study was to analyze prognostic factors for survival in Turkish patients who received chemotherapy after cranial irradiation for NSCLC with brain metastases. Methods: We retrospectively reviewed 698 patients with brain metastases resulting from NSCLC. Ten potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with overall survival (OS). Results: Among the 10 variables for univariate analysis, six were identified to have prognostic significance; these included sex, smoking history, histology, number of brain metastases, extracranial metastases, and neurosurgical resection. Multivariate analysis by the Cox proportional hazard model showed that a smoking history, extracranial metastases, and neurosurgical resection were independent negative prognostic factors for OS. Conclusion: Smoking history, extracranial metastases, and neurosurgical resection were considered independent negative prognostic factors for OS. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for more appropriate treatment options.
Yazarlar (29)
1
Ali İnal
2
Hilmi Kodaz
3
Hatice Odabas
ORCID: 0000-0002-5757-4705
4
Ayse Duran
5
Mehmet Seker
6
Mevlude Inanc
7
Emin Elkiran
8
Yusuf Gunaydin
9
Serkan Menekse
10
Turkan Topcu
11
Zuhat Urakci
12
Didem Tastekin
13
Mehmet Bilici
14
Sener Cihan
15
Caglayan Geredeli
16
Emel Sezer
17
Dogan Uncu
18
Erkan Arpaci
19
Banu Turgut Ozturk
ORCID: 0000-0003-0702-6951
20
Oznur Bal
21
Mükremin Uysal
22
Ozgur Tanriverdi
23
Mahmut Gumus
24
Bala Oven Ustaalioglu
25
Ali Suner
26
Suna Cokmert
27
Ilhan Hacibekiroglu
28
Kubra Aydin
29
Abdurrahman Isikdogan
Anahtar Kelimeler
Brain metastases
non-small cell lung cancer
prognostic factors
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Ankara Numune Education and Research Hospital
Ankara Turkey
Ankara Onkoloji Education and Research Hospital
Ankara Turkey
Atatürk Üniversitesi
Erzurum Turkey
Bezmiâlem Vakıf Üniversitesi
Istanbul Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Erciyes Üniversitesi
Kayseri Turkey
Gaziantep Üniversitesi
Gaziantep Turkey
Gazi Üniversitesi
Ankara Turkey
Haydarpasa Numune Egitim ve Arastýrma Hastanesi
Istanbul Turkey
Inönü Üniversitesi
Malatya Turkey
Istanbul Üniversitesi
Istanbul Turkey
Karadeniz Technical University
Trabzon Turkey
Kartal Education and Research Hospital
Istanbul Turkey
Kayseri Education and Research Hospital
Kayseri Turkey
Manisa Celâl Bayar Üniversitesi
Manisa Turkey
Mersin City Hospital
Mersin Turkey
Mersin Üniversitesi
Mersin Turkey
Muğla Sıtkı Koçman Üniversitesi
Mugla Turkey
Özel Kent Hastanesi, Turkey
Izmir Turkey
Sakarya Üniversitesi
Serdivan Turkey
Tokat Gaziosmanpaşa Üniversitesi
Tokat Turkey
Trakya Üniversitesi
Edirne Turkey
Metrikler
4
Atıf
29
Yazar
3
Anahtar Kelime