Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats
Indian Journal of Animal Research · Haziran 2019
YÖKSİS Kayıtları
Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rat
Indian Journal of Animal Research · 2019 SCI-Expanded
PROFESÖR FATİH HATİPOĞLU →
Comparison of the clinical effects of Prednisolone, Azathioprine and Oligodeoxynucleotide (ODN) applications in experimentally induced endotoxin uveitis in rats
Indian Journal of Animal Research · 2019 SCI-Expanded
PROFESÖR FATİH HATİPOĞLU →
Makale Bilgileri
DergiIndian Journal of Animal Research
Yayın TarihiHaziran 2019
Cilt / Sayfa53 · 827-831
Scopus ID2-s2.0-85117124323
Erişim🔓 Açık Erişim
Özet
Clinical effects and pathological changes of synthetic oligodeoxynucleotide (ODN), prednol (PRD) and azathioprine (AZA) was compared on uveitis treatment in rats. A total of 28 Wistar Albino, female, adult rats were divided into Control (C), PRD, AZA and ODN groups. Uveitis was induced by 176 μg/rat subcutan injection E. coli, LPS and observed in all animals after 48 hours. Then, 0.25 mg/rat/day AZA and 1.25 mg/rat/day of methylprenidolone was administered by gavage in AZA and PRD groups for ten days. In the ODN group, 178 μg/rat ODN was administered IP totally four times. A numerical weight loss was seen in all groups in the course of the infection period, but dropped dramatically in the PRD group during the treatment period. Average value of right and left eye results showed that immunesuppressive effect of Prednol was higher in terms of IOP values compared to others whereas Shirmer test values were the lowest in the post-treatment period. Finally, Prednol was more effective with its immunesuppressive effect resulting in recovery of photophobia, vascularization and oedema in iris vessels.
Yazarlar (4)
1
Tuba Özge Yaşar Erkal
2
Servet Kılıç
3
Fatih Hatipoglu
4
Funda Terzi
ORCID: 0000-0002-6184-5408
Anahtar Kelimeler
Azathioprine
ODN
Prednol
Rat
Uveitis
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Tekirdağ Namık Kemal Üniversitesi
Tekirdag Turkey
Metrikler
1
Atıf
4
Yazar
5
Anahtar Kelime