Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Investigation of the tumor microenvironment, hypoxia and angiogenesis by immunohistochemical and histopathological methods in canine mammary tumors
Veterinarski Arhiv · Ocak 2023
YÖKSİS Kayıtları
Investigation of the tumor microenvironment, hypoxia and angiogenesis by immunohistochemical and histopathological methods in canine mammary tumors
VETERINARSKI ARHIV · 2023 Science Citation Index Expanded (SciSearch®) Journal Citation Reports/Science Edition SCOPUS Zoological Record Biological Abstracts BIOSIS Previews CAB Abstracts (Index Veterinarius, Veterinary Bulletin) FISHLIT
PROFESÖR FATİH HATİPOĞLU →
Makale Bilgileri
DergiVeterinarski Arhiv
Yayın TarihiOcak 2023
Cilt / Sayfa93 · 665-682
Scopus ID2-s2.0-85185250207
Erişim🔓 Açık Erişim
Özet
The tumor microenvironment (TME) is an important component for studying tumor behavior in several cancers in human beings. However, little information regarding the role of the TME in canine mammary tumors (CMTs) is available compared to humans. In this study, the aim was to investigate the relationship between the TME, hypoxia and angiogenesis through CD31, VEGF, HIF-1a, CD68 and CD163 expression by using immunohistochemical (IHC) methods in formalin-fixed paraffin-embedded canine mammary tumor samples [(n=34: malignant (n=28) and benign (n=6)], to compare them with the clinicopathological features of tumors, and to analyze the relationship between them. There was no significant relationship between CD31, VEGF, HIF-1a, CD68 and CD163 expression in malignant tumors compared to benign tumors (P>0.05). There was an association between microvessel density and clinicopathological variables (the tumor size P=0.013, the presence of necrosis P=0.022) and individual histological grade (G2 vs. G3 P=0.028) in malignant tumors. While there was a positive correlation between CD68 and CD163 in malignant tumors in the dogs (P<0.01), no correlation was determined between other antibodies. Immunohistochemical determination of the level of angiogenesis in the TME may give further useful information about the angiogenic potential and grading of the clinical aggressiveness of some CMTs.
Yazarlar (2)
1
Erdinc Guner
2
Fatih Hatipoglu
Anahtar Kelimeler
angiogenesis
canine mammary tumors
tumor-associated macrophages
tumor microenvironment
Kurumlar
Kyrgyz-Turkish Manas University
Bishkek Kyrgyzstan
Selçuk Üniversitesi
Selçuklu Turkey
Solar Pathology Laboratory
Izmir Turkey