Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Investigation of the tumor microenvironment, hypoxia and angiogenesis by immunohistochemical and histopathological methods in canine mammary tumors
Veterinarski Arhiv · Ocak 2023
YÖKSİS Kayıtları
Investigation of the tumor microenvironment, hypoxia and angiogenesis by immunohistochemical and histopathological methods in canine mammary tumors
VETERINARSKI ARHIV · 2023 Science Citation Index Expanded (SciSearch®) Journal Citation Reports/Science Edition SCOPUS Zoological Record Biological Abstracts BIOSIS Previews CAB Abstracts (Index Veterinarius, Veterinary Bulletin) FISHLIT
Prof. Dr. FATİH HATİPOĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The Vomeronasal Organ in Angora Goats Capra Hircus
2001 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. EMRULLAH EKEN →
The Effects of Aflatoxin and Glucomannan on Coagulation Parameters in Rabbits
2009 ISSN: 0372-5480 SCI-Expanded 3 atıf
Prof. Dr. NURCAN DÖNMEZ →
The evaluation of endometrial cytology in cows with acute and chronic endometritis
2015 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Miyocarditis associated with foot and mouth disease in suckling calves
2015 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Comparison of two different primer sets for detection of Pasteurellacaballi in bronchoalveolar lavage fl uids samples from thoroughbred Arabian foals using PCR
2016 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. HASAN HÜSEYİN HADİMLİ →
The relationship of copper concentrations in feed and plasma to developmental orthopedic disease in foals
2016 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
Comparison of two different primer sets for detection of Pasteurellacaballi in bronchoalveolar lavage fluids samples from thoroughbredArabian foals using PCR
2016 ISSN: 0372-5480 SCI-Expanded
Doç. Dr. ASLI BALEVİ →
Comparison of two different primer sets for detection of Pasteurellacaballi in bronchoalveolar lavage fl uids samples from thoroughbredArabian foals using PCR
2016 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. MEHMET MADEN →
The Vomeronasal Organ In Angora Goats Capra Hircus
2001 ISSN: 0372-5480 SCI-Expanded
Prof. Dr. KAMİL BEŞOLUK →
The Vomeronasal Organ in Angora Goats (Capra hircus)
2001 ISSN: 0372-5480 SCI
Prof. Dr. KAMİL BEŞOLUK →
Histological and histomorphometric studies on the cerebellar cortex and silver stained nucleolus organizer regions of Purkinje neurons in chronic morphine-treated rats
2018 ISSN: 0372-5480 SCI
Prof. Dr. İLHAMİ ÇELİK →
The impact of ambroxol on the anti-inflammatory effect of azithromycin in
lung tissue
2021 ISSN: 0372-5480 pub med
Prof. Dr. AYŞE ER →
The effect of intra-articular platelet-rich plasma, bio-physically activated
PRP and mesenchymal stem cell administration for interleukins in dogs
with osteoarthritis
2022 ISSN: 0372-5480 SCI-Expanded Q3
Doç. Dr. KURTULUŞ PARLAK →
The effect of intra-articular platelet-rich plasma, bio-physically activated PRP and mesenchymal stem cell administration for interleukins in dogs with osteoarthritis
2022 ISSN: 0372-5480 SCI-Expanded Q4
Prof. Dr. KAMİL ÜNEY →
The protective effects of Nigella sativa, thymoquinone and bentonite in experimental aflatoxicosis model in broilers
2023 ISSN: 0372-5480 SCI-Expanded Q4
Doç. Dr. MEHMET BURAK ATEŞ →
Investigation of the tumor microenvironment, hypoxia and angiogenesis by immunohistochemical and histopathological methods in canine mammary tumors
2023 ISSN: 0372-5480 Science Citation Index Expanded (SciSearch®) Journal Citation Reports/Science Edition SCOPUS Zoological Record Biological Abstracts BIOSIS Previews CAB Abstracts (Index Veterinarius, Veterinary Bulletin) FISHLIT
Prof. Dr. FATİH HATİPOĞLU →
The protective effects of Nigella sativa, thymoquinone and bentonite in experimental aflatoxicosis model in broilers
2023 ISSN: 0372-5480 CABI, EBSCO, Scobus
Prof. Dr. MUSTAFA ORTATATLI →
The protective effects of Nigella sativa, thymoquinone and bentonite
in experimental aflatoxicosis model in broilers
2023 ISSN: 0372-5480 SCI-Expanded Q4
Prof. Dr. HALİS UĞUZ →
In-vitro antiviral activity of Neem (Azadirachta indica L.) Bark extract against
BCoV, BHV-1, BPIV-3, and BEVs
2025 ISSN: 0372-5480 SCI-Expanded
Arş. Gör. HATİCE PELİN ASLIM →
High point seroprevalence of Toxoplasma gondii and Neospora caninum in sheep with abortion history in the central part of Türkiye
2025 ISSN: 0372-5480 SCI-Expanded
Doç. Dr. ONUR CEYLAN →
Makale Bilgileri
Dergi
Veterinarski Arhiv
ISSN03725480
Yayın TarihiOcak 2023
Cilt / Sayfa93 · 665-682
Scopus ID2-s2.0-85185250207
Erişim🔓 Açık Erişim
Özet
The tumor microenvironment (TME) is an important component for studying tumor behavior in several cancers in human beings. However, little information regarding the role of the TME in canine mammary tumors (CMTs) is available compared to humans. In this study, the aim was to investigate the relationship between the TME, hypoxia and angiogenesis through CD31, VEGF, HIF-1a, CD68 and CD163 expression by using immunohistochemical (IHC) methods in formalin-fixed paraffin-embedded canine mammary tumor samples [(n=34: malignant (n=28) and benign (n=6)], to compare them with the clinicopathological features of tumors, and to analyze the relationship between them. There was no significant relationship between CD31, VEGF, HIF-1a, CD68 and CD163 expression in malignant tumors compared to benign tumors (P>0.05). There was an association between microvessel density and clinicopathological variables (the tumor size P=0.013, the presence of necrosis P=0.022) and individual histological grade (G2 vs. G3 P=0.028) in malignant tumors. While there was a positive correlation between CD68 and CD163 in malignant tumors in the dogs (P<0.01), no correlation was determined between other antibodies. Immunohistochemical determination of the level of angiogenesis in the TME may give further useful information about the angiogenic potential and grading of the clinical aggressiveness of some CMTs.
Yazarlar (2)
1
Erdinc Guner
2
Fatih Hatipoglu
Anahtar Kelimeler
angiogenesis
canine mammary tumors
tumor-associated macrophages
tumor microenvironment
Kurumlar
Kyrgyz-Turkish Manas University
Bishkek Kyrgyzstan
Selçuk Üniversitesi
Selçuklu Turkey
Solar Pathology Laboratory
Izmir Turkey
Scimago Dergi (ISSN Eşleşmesi)
Veterinarski Arhiv
Q3
OA
SJR Skoru0,208
H-Index38
YayıncıUniversity of Zagreb, Facultty of Veterinary Medicine
ÜlkeCroatia
Veterinary (miscellaneous) (Q3)