Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rat's brain and sciatic nerve
Clinical and Experimental Pharmacology and Physiology · Mart 2024
YÖKSİS Kayıtları
Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rats brain and sciatic nerve
Clinical and Experimental Pharmacology and Physiology · 2024 SCI-Expanded
DOÇENT MEHMET BURAK ATEŞ →
Metabolomic modelling and neuroprotective effects of carvacrol against acrylamide toxicity in rats brain and sciatic nerve
Clinical and Experimental Pharmacology and Physiology · 2024 SCI-Expanded
DOÇENT DURMUŞ HATİPOĞLU →
Makale Bilgileri
DergiClinical and Experimental Pharmacology and Physiology
Yayın TarihiMart 2024
Cilt / Sayfa51
Scopus ID2-s2.0-85182624588
Erişim🔓 Açık Erişim
Özet
The study aimed to investigate the harmful effects of acrylamide (AA), which forms in carbohydrate-rich foods at temperatures above 120°C, on the central and peripheral nervous systems and to evaluate the potential neuroprotective effects of carvacrol (CRV). Male Wistar Albino rats were subjected to AA (40 mg/kg/bw/day) and CRV (50 mg/kg/bw/day) for 15 days. Following the last administration, evaluations revealed disrupted gait, heightened thermal sensitivity and altered paw withdrawal thresholds in AA-exposed rats. Notably, AA reduced glutathione (GSH) and raised malondialdehyde (MDA) levels in both brain and sciatic nerve tissues. AA raised nuclear factor erythroid 2-related factor 2 (Nrf2), caspase 3 and nuclear factor κB (NF-κB) gene expressions while decreasing NR4A2. CRV co-administration mitigated gait abnormalities, elevated GSH levels and lowered MDA levels in both tissues. CRV also modulated gene expression, reducing Nrf2 and NF-κB while increasing NR4A2. Histopathological signs of AA-induced neurodegeneration and elevated glial fibrillary acidic protein levels observed in brain and sciatic nerve tissues were rectified with simultaneous administration of CRV, thereby demonstrating neuroprotective efficacy in both regions. This study is pioneering in demonstrating CRV's neuroprotective potential against AA-induced neurotoxicity in both central and peripheral nervous systems, effectively addressing limitations in the literature. In conclusion, the study revealed AA-induced neurodegeneration in the brain and sciatic nerve, with CRV significantly mitigating this neurotoxicity. This novel research underscores CRV's promise as a neuroprotective agent against AA-induced adverse effects in both the central and peripheral nervous systems.
Yazarlar (4)
1
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
2
Ates M. Burak
3
Senturk Goktug
4
Bulut Aysegul
Anahtar Kelimeler
acrylamide
carvacrol
neurodegeneration
neuroprotection
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
4
Yazar
4
Anahtar Kelime