Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY
Trakya University Journal of Natural Sciences · Nisan 2021
YÖKSİS Kayıtları
THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY
Trakya University Journal of Natural Sciences · 2021 Emerging Sorches Sciences index
Prof. Dr. HASAN HÜSEYİN DOĞAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
EVALUATION OF THE ANTIVIRAL ACTIVITY OF Ballota glandulosissima Hub.-Mor. Patzak EXTRACTS AGAINST RESPIRATORY SYNCYTIAL VIRUS (RSV)
2019 ISSN: 2147-0294 Emerging Sources Citation Index, TR Dizin
Prof. Dr. HASAN HÜSEYİN DOĞAN →
NOTES ON Arabis kaynakiae Daşkın (Brassicaceae), A CRITICALLY ENDANGERED SPECIES ENDEMIC TO TURKEY
2020 ISSN: 2147-0294 TR DİZİN
Doç. Dr. EMRAH ŞİRİN →
THE MYCOBIOTA OF SAMANLI MOUNTAINS IN TURKEY
2021 ISSN: 2147-0294 Emerging Sorches Sciences index
Prof. Dr. HASAN HÜSEYİN DOĞAN →
THE ANTI HRSV ACTIVITY OF Ferula halophila Peşmen AQUEOUS AND METHANOL EXTRACT BY MTT ASSAY
2021 ISSN: 2147-0294 Emerging Sorches Sciences index
Prof. Dr. HASAN HÜSEYİN DOĞAN →
A NEW TRUFFLE SPECIES ADDITION, TUBER MACROSPORUM, TO TURKISH MYCOTA
2021 ISSN: 2147-0294 Emerging Sorches Sciences index
Prof. Dr. HASAN HÜSEYİN DOĞAN →
Biological activity evaluation of three Hypericum species wild growing in Sivas province of Turkey
2022 ISSN: 2147-0294 Web of Science - Emerging Sources Citation Index (ESCI)
Prof. Dr. NURANİYE ERUYGUR →
Natural Treatment Approaches For Varicose Veins: A Brief Review Of The Literature
2024 ISSN: 2147-0294 ESCI
Arş. Gör. TUĞSEN BÜYÜKYILDIRIM →
Makale Bilgileri
ISSN21470294
Yayın TarihiNisan 2021
Cilt / Sayfa22 · 43-48
Scopus ID2-s2.0-85149259789
Erişim🔓 Açık Erişim
Özet
The trend towards natural products in the world is increasing due to the increased drug resistance of infectious diseases, the high prices for drugs and the difficulty of access. Also, bacterial or viral diseases that are difficult to treat and need a long time for proper treatment cause important infections in people. Since effective drugs could not be developed for most viral infections, it is very important to find natural products against viruses to introduce them to the world of science. The antiviral activities of the aqueous and methanol extract from Ferula halophila Peşmen, an endemic species to Turkey, has been investigated against human respiratory syncytial virus (HRSV, ATCC-VR-26). The cytotoxic and antiviral properties of plant extracts were investigated in HRSV / HEp-2 cell systems, respectively by the colorimetric MTT assay. In the study, the titer of RSV was used as 100 TCID50 (50% tissue culture infective dose). While MNTC (Maximum non-toxic concentration) of methanol extract was 195.313 µg/mL and CC50 (50% cytotoxic concentration) was 4366.22 µg/mL, it was determined as MNTC = 390.625 µg/mL and CC50 = 4366.22 for aqueous extract. According to the results, methanol extract showed more toxicity than the aqueous extract. The MNTC of Ribavirin used as a positive control was determined as 0.98 µg/mL and CC50 was 110.40 µg/mL. As a result of the study, it was determined that the methanol extract was not effective, whereas the aqueous extract had a significant anti-HRSV activity with the values of 50.69 µg/mL EC50 (50% Effective Concentration) and 97.54 Selectivity Index (SI). The EC50 and SI values of Ribavirin were 2.39 µg/mL and 46.19, respectively. According to the results, we can explain the presence of antiviral activity only in the aqueous extract and the absence in the methanol extract by the high toxicity of it and the insolubility of the antiviral compounds in the methanol extract.
Yazarlar (2)
1
Hasan Huseyin Dogan
2
Rüstem Duman
Anahtar Kelimeler
Antiviral activity
Cytotoxicity
Ferula halophila
Human respiratory syncytial virus
Methanol and aqueous extract
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Trakya University Journal of Natural Sciences
Q4
OA
SJR Skoru0,225
H-Index7
ÜlkeTurkey
Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q4)
Molecular Biology (Q4)
Metrikler
8
Atıf
2
Yazar
5
Anahtar Kelime