Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
In vitro evaluation of the chemical composition and various biological activities of ficus carica leaf extracts
Turkish Journal of Pharmaceutical Sciences · Ocak 2019
YÖKSİS Kayıtları
In vitro Evaluation of Chemical Composition and Various Biological Activities of Ficus carica Leaves Extracts
Turkish Journal of Pharmaceutical Science · 2019 Scopus
PROFESÖR NURANİYE ERUYGUR →
Makale Bilgileri
DergiTurkish Journal of Pharmaceutical Sciences
Yayın TarihiOcak 2019
Cilt / Sayfa16 · 401-409
Scopus ID2-s2.0-85076514713
Erişim🔓 Açık Erişim
Özet
Objectives: The present study aimed to investigate the inhibitory activities of enzymes related to diabetes mellitus and Alzheimer’s disease of the methanol and water extracts of Ficus carica leaf extracts. The bioactive compounds and anticancer, antioxidant, and antimicrobial effects of the extracts were also investigated. Materials and Methods: The bioactive compounds in the extracts were determined by gas chromatography-mass spectrometry. The antioxidant activity was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6 sulphonic acid) (ABTS) radical scavenging, total phenol and flavonoid content, ferric reducing power, and iron chelating method. The anticancer, anticholinesterase, and antimicrobial effects were investigated using the XTT assay, Ellman method, and microdilution, respectively. Results: Our results showed that between the water and methanol extracts there was a difference in terms of chemical composition. The antioxidant results suggested that both extracts have strong antioxidant activity. Similarly, both extracts showed strong α-glucosidase and α-amylase inhibition activity, while the water extract had higher inhibition activity than the methanol extract against acetylcholinesterase and butyrylcholinesterase. The methanol extract of F. carica exhibited significant anticancer activity on MDA-MB-231 cells and showed moderate antimicrobial activities against Escherichia coli and Staphylococcus aureus. Conclusion: Our results suggest that F. carica leaves could be a valuable source for developing a promising therapeutic agent in cancer, diabetes, and Alzheimer’s disease.
Yazarlar (5)
1
M. Ergul
2
Merve Ergul
3
Nuraniye Eruygur
4
Mehmet Ataş
5
Esra Uçar
Anahtar Kelimeler
Alzheimer’s disease
Anticancer and antimicrobial activities
Antioxidant activity
Diabetes
Ficus carica
Kurumlar
Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
22
Atıf
5
Yazar
5
Anahtar Kelime