Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Anticancer Activity of Water and Methanol Extracts of Hypericum scabrum L. on Different Cancer Cell Lines
Notulae Scientia Biologicae · Ocak 2019
YÖKSİS Kayıtları
Anticancer Activity of Water and Methanol Extracts of Hypericum scabrum L. on Different Cancer Cell Lines
Notulae Scientia Biologicae · 2019 Scopus
PROFESÖR NURANİYE ERUYGUR →
Makale Bilgileri
DergiNotulae Scientia Biologicae
Yayın TarihiOcak 2019
Cilt / Sayfa11 · 333-336
Scopus ID2-s2.0-85117617520
Erişim🔓 Açık Erişim
Özet
Hypericum scabrum L. is an endemic medicinal plant with antimicrobial, anticancer and anti-inflammatory, antiviral effect. In this study, we aimed to investigate the cytotoxic effect of water and methanol extracts on different cancer cell lines such as osteosarcoma cancer, cervical cancer and prostate cancer. The data showed that the methanol extract had a highly effective cytotoxic effect on all three cell lines. Although water extract caused less cell loss than methanol extract, it was found that the cells were inhibited in all three cell lines. DU-145, which is the prostate cell line, was more effective in both extracts. As a result, the water and methanol extract of Hypericum scabrum L. have an anticancer effect on Saos-2, HeLa and DU-145 cells. There is a need for further and comprehensive studies by isolating the main active ingredient of this plant which is a candidate for drug of cancer in the future. Our study is expected to lead the studies in this direction.
Yazarlar (5)
1
Gulsen Guclu
ORCID: 0000-0002-3599-213X
2
Ayca Tas
3
Manhal Tulimat
4
Nuraniye Eruygur
5
Yavuz Silig
Anahtar Kelimeler
cancer
cytotoxic
DU-145
HeLa
Hypericum scabrum
Saos-2
Kurumlar
Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
5
Yazar
6
Anahtar Kelime