Scopus
YÖKSİS DOI Eşleşti
SJR Q2
In vitro antioxidant assessment, screening of enzyme inhibitory activities of methanol and water extracts and gene expression in Hypericum lydium
Molecular Biology Reports · Nisan 2019
YÖKSİS Kayıtları
In vitro antioxidant assessment, screening of enzyme inhibitory activities of methanol and water extracts and gene expression in Hypericum lydium
Molecular Biology Reports · 2019 SCI
Prof. Dr. NURANİYE ERUYGUR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Decision tree-based evaluation of IGF-1 and CAST gene polymorphisms associated with morphometric traits in sheep
2026 ISSN: 0301-4851 SCI Q3
Arş. Gör. AYŞE NUR TANIŞ →
Glutathione S-transferase M1 and T1 genotypes and myocardial infarction
2013 ISSN: 0301-4851 IM: Index Medicus
Prof. Dr. TÜLÜN ÇORA →
In vitro antioxidant assessment, screening of enzyme inhibitory activities of methanol and water extracts and gene expression in Hypericum lydium
2019 ISSN: 0301-4851 SCI
Prof. Dr. NURANİYE ERUYGUR →
NF‑ĸβ upregulates ADAMTS5 expression by direct binding after TNF‑α
treatment in OUMS‑27 chondrosarcoma cell line 2020 Jun;47(6):4215-4223
2020 ISSN: 0301-4851 SSCI
Prof. Dr. TÜLÜN ÇORA →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
2021 ISSN: 0301-4851 SCI-Expanded Q4
Arş. Gör. FATMA GÖKTÜRK →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
2021 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. MERİH ÖNAL →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge
between circadian rhythm and glucose metabolism, in a Turkish
population
2021 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. DUDU ERKOÇ KAYA →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
2021 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
2021 ISSN: 0301-4851 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study
2022 ISSN: 0301-4851 SCI-Expanded Q4
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Glutathione S transferase M1 and T1 genotypes and myocardial infarction
2013 ISSN: 0301-4851 SCI
Prof. Dr. HASAN ACAR →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. HÜSAMETTİN VATANSEV →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. BAHADIR ÖZTÜRK →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi DUYGU DURSUNOĞLU →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. DUDU ERKOÇ KAYA →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. ESMA MENEVŞE →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. HÜSAMETTİN VATANSEV →
Investigation of the effects of gabapentin on high glucose-induced neurotoxicity and genotoxicity in an in vitro model of diabetic neuropathy and in silico molecular docking analysis
2025 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi BATUHAN BİLGİN →
Comparison of the neuroprotective effects of gossypin on cisplatin-induced neurotoxicity in vitro and in vivo
2025 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Makale Bilgileri
ISSN03014851
Yayın TarihiNisan 2019
Cilt / Sayfa46 · 2121-2129
Scopus ID2-s2.0-85061656952
Özet
Hypericum lydium Boiss. is a perennial plant of the Hypericaceae family, which has been used in particular to treat depression. The aim of this study was to determine in vitro antioxidant, antimicrobial activities, anticholinesterase (acetylcholinesterase (AChE)/butyrylcholinesterase (BChE)), antidiabetic activities (α-glucosidase/α-amylase) and Tyrosinase inhibitor activity of methanol and water extracts of H. lydium. Also, gene expression has been evaluated in the shoot and root by microarray technology. So, in general, the purpose of this study is to study the active molecules such as antioxidant, antimicrobial, antidiabetic, enzymes and genes in the plant, which is the first to be reported. The experiments were conducted in a completely randomized design with three replications. In addition, gene expression was compared in the shoot and root parts. Expression profiling was carried out by microarrays. According to the results, the highest chemical components were determined in methanol extract rather than water extract. There was a difference between the obtained components. While the highest antioxidant activity was determined from the methanol extract of plant herbs for DPPH Free Radical Scavenging Activity, antioxidant activity was the same in both methanol and water extracts using the ABTS method. The methanol extract demonstrated stronger anticholinesterase (AChE and BChE) and α-amylase inhibition activity. This study was complemented by the detection of antioxidant activity and some enzyme inhibition activity in the methanol extract. Microarray showed 10,784 genes had significantly different expression in root and shoot. There was a positive effect of methanol extract in respect of different activities compared to the water extract. Gene expression showed that the number of expressed genes in the root was greater than the shoot.
Yazarlar (6)
1
Nuraniye Eruygur
2
Esra Uçar
3
Hüseyin Aşkın Akpulat
4
Keyhan Shahsavari
ORCID: 0000-0003-1805-3998
5
Seyed Mehdi Safavi
ORCID: 0000-0003-1447-8091
6
Danial Kahrizi
Anahtar Kelimeler
Anticholinesterase
Antimicrobial and antidiabetic activity
Gene expression
Hypericum lydium
Kurumlar
Cumhuriyet Üniversitesi
Sivas Turkey
Islamic Azad University, Kermanshah Branch
Kermanshah Iran
Medical Biology Research Center, Kermanshah University of Medical Sciences
Kermanshah Iran
Razi University
Kermanshah Iran
Selçuk Üniversitesi
Selçuklu Turkey
Zagros Bioidea Company
Kermanshah Iran
Scimago Dergi (ISSN Eşleşmesi)
Molecular Biology Reports
Q2
SJR Skoru0,743
H-Index103
YayıncıSpringer Science and Business Media B.V.
ÜlkeNetherlands
Genetics (Q2)
Medicine (miscellaneous) (Q2)
Molecular Biology (Q3)
Metrikler
48
Atıf
6
Yazar
4
Anahtar Kelime