Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
BIOLOGICAL ACTIVITY EVALUATION OF THREE Hypericum L. SPECIES
Trakya University Journal of Natural Sciences · Ekim 2022
YÖKSİS Kayıtları
Biological activity evaluation of three Hypericum species wild growing in Sivas province of Turkey
Trakya University Journal of Natural Sciences · 2022 Web of Science - Emerging Sources Citation Index (ESCI)
PROFESÖR NURANİYE ERUYGUR →
Makale Bilgileri
DergiTrakya University Journal of Natural Sciences
Yayın TarihiEkim 2022
Cilt / Sayfa23 · 125-134
Scopus ID2-s2.0-85205591066
Erişim🔓 Açık Erişim
Özet
This study was performed in order to evaluate in vitro antioxidant, anti-Trichomonas vaginalis, antimicrobial and cytotoxic activities of methanol extracts of aerial parts of Hypericum perforatum L., H. thymbrifolium Boiss. & Noë and H. thymopsis Boiss. The antioxidant activity of methanol extracts was tested with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging and iron chelating assays. The total phenol and flavonoid contents were also determined spectrophotometrically. Cytotoxicity and apoptosis were evaluated on MCF-7 breast cancer and PC3 prostate cancer cell line. Antimicrobial activities were evaluated by the microdilution method on the bacterial strains Staphylococcus aureus (ATCC 29213), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853) Escherichia coli (ATCC 25922) and the fungal strain Candida albicans (ATCC 10231). All extracts demonstrated cytotoxic activity on PC3 prostat cancer cell line with a concentration dependent manner, while H. thymopsis extract was the most active against cancer cell growth. The obtained results of the present study revealed that the methanol extract of H. perforatum, H. thymbrifolium and H. thymopsis have significant antioxidant and cytotoxic activities. The results provided the basic research data for further phytochemical and biological activity guided investigations on these species for identication and isolation of potential drug active compounds.
Yazarlar (6)
1
Nuraniye Eruygur
2
Necati Ozpinar
ORCID: 0000-0002-7317-885X
3
Hülya Ozpinar
ORCID: 0000-0001-8154-0874
4
Mehmet Ataş
5
Mehmet Tekin
ORCID: 0000-0003-1837-7917
6
Ozge Çevik
ORCID: 0000-0002-9325-3757
Anahtar Kelimeler
Antimicrobial
Antioxidant
Anti-Trichomonas
Cytotoxicity
Hypericum perforatum
Hypericum thymbrifolium
Hypericum thymopsis
Kurumlar
Aydin Adnan Menderes University
Aydin Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Trakya Üniversitesi
Edirne Turkey