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The pharmacological properties of Gypsophila eriocalyx: The endemic medicinal plant of northern central Turkey

International Journal of Biological Macromolecules · Mayıs 2024

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YÖKSİS Kayıtları
The pharmacological properties of Gypsophila eriocalyx: The endemic medicinal plant of northern central Turkey
International Journal of Biological Macromolecules · 2024 SCI-Expanded
Prof. Dr. NURANİYE ERUYGUR →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 0141-8130 SCI 2 atıf
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Binding of actin to thioglycolic acid modified superparamagnetic nanoparticles for antibody conjugation
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Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 01418130 SCI-Expanded 1 atıf
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Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
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2009 ISSN: 0141-8130 SCI-Expanded
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Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
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Synthesis and characterization of novel nano chitosan Schiff base and use of lead II sensor
2012 ISSN: 01418130 SCI-Expanded 7 atıf
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Chitosan sporopollenin microcapsules Preparation characterisation and application in heavy metal removal
2015 ISSN: 01418130 SCI-Expanded
Prof. Dr. GÜLŞİN ARSLAN →
Immobilization and characterization of hemoglobin on modified sporopollenin surfaces
2012 ISSN: 01418130 SCI-Expanded 1 atıf
Prof. Dr. İLKAY HİLAL GÜBBÜK →
Magnetic nanoparticles serum proteins bioconjugates for binding of irinotecan
2015 ISSN: 01418130 SCI-Expanded 2 atıf
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Characteristics of corneal lens chitin in dragonfly compound eyes
2016 ISSN: 01418130 SCI
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Evaluation of antibacterial properties on polysulfone composite membranes using synthesized biogenic silver nanoparticles with Ulva compressa (L.) Kütz. and Cladophora glomerata (L.) Kütz. extracts
2018 ISSN: 01418130 SSCI
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Supplementing capsaicin with chitosan-based films enhanced the anti-quorum sensing, antimicrobial, antioxidant, transparency, elasticity and hydrophobicity
2018 ISSN: 0141-8130 SCI
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Characteristics of corneal lens chitin in dragonfly compound eyes
2016 ISSN: 01418130 SCI
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Chitin extraction and characterization from Daphnia magna resting eggs
2013 ISSN: 0141-8130 SCI
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Chitosan nanofiber production from Drosophila by electrospinning
2016 ISSN: 01418130 SCI
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Chitosan/sporopollenin microcapsules: Preparation, characterisation and application in heavy metal removal
2015 ISSN: 01418130 SCI
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Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
2017 ISSN: 01418130 SCI
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Detailed adsorption mechanism of plasmid DNA by newly isolated cellulose from waste flower spikes of Thypa latifolia using quantum chemical calculations
2017 ISSN: 01418130 SCI
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Effect of different animal fat and plant oil additives on physicochemical, mechanical, antimicrobial and antioxidant properties of chitosan films
2018 ISSN: 0141-8130 SCI
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Makale Bilgileri

Dergi International Journal of Biological Macromolecules
ISSN01418130
Yayın TarihiMayıs 2024
Cilt / Sayfa266
DOI10.1016/j.ijbiomac.2024.130943
Scopus ID2-s2.0-85189550481
Özet The aim of this study is to evaluate and compare the biological properties of different extracts (methanol, ethanol, and water) obtained from Gypsophila eriocalyx (G. eriocalyx), a medicinal plant traditionally used in Turkey. The components of different extracts were defined using the GC–MS method. The effects of G. eriocalyx extracts on cell proliferation, apoptosis, and cell cycle arrest in MDA-MB-231 breast cancer as well as in vitro antioxidant, enzyme inhibition, and antimicrobial activities were investigated. In accordance with the results obtained, although ethanol and methanol extracts of G. eriocalyx show higher antioxidant activity than G. eriocalyx water extract, enzyme inhibition activities of the extracts were not found to be significant compared to the reference drug. The methanol and ethanol extract of G. eriocalyx exhibited moderate antimicrobial activity against Staphylococcus aureus and methanol extract showed significant antimicrobial activity against Bacillus cereus. In addition, both extracts significantly inhibited cell viability in a dose-dependent manner in breast cancer cells. The cell growth inhibition by methanol and ethanol extracts induced S phase cell-cycle arrest and apoptosis in MDA-MB-231 cells. Lastly, in order to compare the activities of the chemicals found in Gypsophila eriocalyx plant extract, their activities against various proteins that are breast cancer protein (PDB ID:1A52 and 1JNX), antioxidant protein (PDB ID: 1HD2), AChE enzyme protein (PDB ID: 4M0E), BChE enzyme protein (PDB ID: 5NN0), and Escherichia coli protein (PDB ID: 4PRV)were compared. Then, ADME/T analysis calculations were made to examine the effects of molecules with high activity on human metabolism. Eventually, G. eriocalyx is thought to be a potent therapeutic herb that can be considered as an alternative and functional therapy for the management of diseases of a progressive nature related to oxidative damage such as infection, diabetes, cancer, and Alzheimer's disease.

Yazarlar (6)

1
Merve İnanir
ORCID: 0000-0003-4661-8087
2
Esra Uçar
3
Burak Tüzün
ORCID: 0000-0002-0420-2043
4
Nuraniye Eruygur
5
Mehmet Ataş
6
Hüseyin Aşkın Akpulat

Anahtar Kelimeler

Antiapoptotic Anticancer Antioxidant Enzyme inhibition Gypsophila eriocalyx Molecular docking

Kurumlar

Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
International Journal of Biological Macromolecules
Q1
SJR Skoru1,287
H-Index247
YayıncıElsevier B.V.
ÜlkeNetherlands
Biochemistry (Q1)
Biomaterials (Q1)
Food Science (Q1)
Structural Biology (Q1)
Molecular Biology (Q2)
Dergi sayfasına git

Metrikler

16
Atıf
6
Yazar
6
Anahtar Kelime

Sistemimizdeki Yazarlar

NE
NURANİYE ERUYGUR
Prof. Dr.

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