Scopus
YÖKSİS Eşleşti
The pharmacological properties of Gypsophila eriocalyx: The endemic medicinal plant of northern central Turkey
International Journal of Biological Macromolecules · Mayıs 2024
YÖKSİS Kayıtları
The pharmacological properties of Gypsophila eriocalyx: The endemic medicinal plant of northern central Turkey
International Journal of Biological Macromolecules · 2024 SCI-Expanded
PROFESÖR NURANİYE ERUYGUR →
Makale Bilgileri
DergiInternational Journal of Biological Macromolecules
Yayın TarihiMayıs 2024
Cilt / Sayfa266
Scopus ID2-s2.0-85189550481
Özet
The aim of this study is to evaluate and compare the biological properties of different extracts (methanol, ethanol, and water) obtained from Gypsophila eriocalyx (G. eriocalyx), a medicinal plant traditionally used in Turkey. The components of different extracts were defined using the GC–MS method. The effects of G. eriocalyx extracts on cell proliferation, apoptosis, and cell cycle arrest in MDA-MB-231 breast cancer as well as in vitro antioxidant, enzyme inhibition, and antimicrobial activities were investigated. In accordance with the results obtained, although ethanol and methanol extracts of G. eriocalyx show higher antioxidant activity than G. eriocalyx water extract, enzyme inhibition activities of the extracts were not found to be significant compared to the reference drug. The methanol and ethanol extract of G. eriocalyx exhibited moderate antimicrobial activity against Staphylococcus aureus and methanol extract showed significant antimicrobial activity against Bacillus cereus. In addition, both extracts significantly inhibited cell viability in a dose-dependent manner in breast cancer cells. The cell growth inhibition by methanol and ethanol extracts induced S phase cell-cycle arrest and apoptosis in MDA-MB-231 cells. Lastly, in order to compare the activities of the chemicals found in Gypsophila eriocalyx plant extract, their activities against various proteins that are breast cancer protein (PDB ID:1A52 and 1JNX), antioxidant protein (PDB ID: 1HD2), AChE enzyme protein (PDB ID: 4M0E), BChE enzyme protein (PDB ID: 5NN0), and Escherichia coli protein (PDB ID: 4PRV)were compared. Then, ADME/T analysis calculations were made to examine the effects of molecules with high activity on human metabolism. Eventually, G. eriocalyx is thought to be a potent therapeutic herb that can be considered as an alternative and functional therapy for the management of diseases of a progressive nature related to oxidative damage such as infection, diabetes, cancer, and Alzheimer's disease.
Yazarlar (6)
1
Merve İnanir
ORCID: 0000-0003-4661-8087
2
Esra Uçar
3
Burak Tüzün
ORCID: 0000-0002-0420-2043
4
Nuraniye Eruygur
5
Mehmet Ataş
6
Hüseyin Aşkın Akpulat
Anahtar Kelimeler
Antiapoptotic
Anticancer
Antioxidant
Enzyme inhibition
Gypsophila eriocalyx
Molecular docking
Kurumlar
Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
6
Yazar
6
Anahtar Kelime