Scopus
YÖKSİS ISSN Eşleşti
SJR Q2
Evaluation of antioxidant, antimicrobial, enzyme inhibition activity, and cell viability capacity of Hypericum heterophyllum vent., an endemic species in Turkey's Flora
Journal of Molecular Structure · Temmuz 2024
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Makale Bilgileri
ISSN00222860
Yayın TarihiTemmuz 2024
Cilt / Sayfa1307
Scopus ID2-s2.0-85187200712
Özet
The aim of this study was determined the antioxidant, antimicrobial, enzyme inhibition activity, and cell viability capacity of H. heterophyllum (endemic species in the Flora of Turkey) extracts. H. heterophyllum methanolic extract was used in this study. H. heterophyllum plants collected at the beginning of flowering and during full flowering. P content was determined with calorimetrically in spectrophotometer. K, CA, Mg, Fe, Mn, Zn and Cu was determined with Atomic Absorption and N concentration were determined according to the Kjeldahl distillation method. H. heterophyllum (endemic species in the Flora of Turkey) extract was evaluated for its antioxidant (DPPH, ABTS, total phenol and flavonoid content), antimicrobial (four bacteria (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cereus) and two Candida species (Candida albicans and Candida tropicalis)), enzyme inhibition activity (ɑ-glucosidase, ɑ-amylase, acetylcholinesterase, butyrylcholinesterase, tyrosinase), and cell viability (XTT assay) capacity. Extracts from the beginning of flowering period showed stronger biological activity. It has been determined that the extracts have antioxidant, antibacterial (against Staphylococcus aureus) anticancer activity (on breast cancer cells), and inhibition effects of BChE and alpha-glucosidase. It has been determined that the extracts obtained from H. heterophylum have important pharmacological activities, and the plant exhibits higher activity in the BF period. Hypericum heterophyllum Vent. The activities of the chemicals contained in it against various proteins that are α-gly enzyme (PDB ID: 1R47), AChE enzyme (PDB ID: 4M0E), BChE enzyme (PDB ID: 5NN0), alpha-Amylase (PDB ID: 3BAJ), breast cancer protein (PDB ID: 1A52 and 1JNX), were compared. ADME/T analysis of molecules with high activity was performed.
Yazarlar (9)
1
Nuraniye Eruygur
2
Esra Uçar
3
Burak Tüzün
ORCID: 0000-0002-0420-2043
4
Mehmet Ataş
5
Merve İnanir
ORCID: 0000-0003-4661-8087
6
Ahmet Demirbaş
7
Halil Bal
ORCID: 0000-0002-0017-3425
8
Belgin Coşge Şenkal
ORCID: 0000-0001-7330-8098
9
Tansu Uskutoğlu
Anahtar Kelimeler
Biological activity
Extract
Flowering
Hypericum
In silico
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Pamukkale Üniversitesi
Denizli Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Molecular Structure
Q2
SJR Skoru0,628
H-Index134
YayıncıElsevier B.V.
ÜlkeNetherlands
Analytical Chemistry (Q2)
Inorganic Chemistry (Q2)
Organic Chemistry (Q2)
Spectroscopy (Q2)
Metrikler
20
Atıf
9
Yazar
5
Anahtar Kelime