Scopus
YÖKSİS Eşleşti
Pharmacokinetics of tolfenamic acid in goats after different administration routes
Journal of Veterinary Pharmacology and Therapeutics · Mayıs 2021
YÖKSİS Kayıtları
Pharmacokinetics of tolfenamic acid in goats after different administration routes
Journal of Veterinary Pharmacology and Therapeutics · 2021 SCI-Expanded
PROFESÖR HALİS UĞUZ →
Pharmacokinetics of tolfenamic acid in goats after different administration routes
Journal of Veterinary Pharmacology and Therapeutics · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiMayıs 2021
Cilt / Sayfa44 · 367-373
Scopus ID2-s2.0-85100908473
Özet
The aim of this study was to determine the pharmacokinetics and bioavailability of tolfenamic acid in goats after intravenous (IV), intramuscular (IM), subcutaneous (SC), and oral (PO) administrations at 2 mg/kg dose. In this study, eight clinically healthy goats were used. The study comprised four periods, according to a crossover design with at least a 15-day washout period between treatments. Plasma concentrations of tolfenamic acid were determined by HPLC-UV, and the pharmacokinetic parameters were estimated using a non-compartmental method. Following IV administration, terminal elimination half-life, volume of distribution at steady state, and total clearance were 1.60 h, 0.37 L/kg, and 0.27 L/h/kg, respectively. The mean peak plasma concentration following IM, SC, and PO administrations was 1.77, 1.22, and 0.30 μg/ml, respectively. The mean bioavailability following IM, SC, and PO administrations was 64.46, 55.43, and 19.46%, respectively. The PO route, which exhibits both the low plasma concentration and bioavailability, is not recommended in goats. The IV, IM, and SC routes, which show comparable pharmacokinetic profiles, may be proposed for use in goats. However, the multi-dose and pharmacodynamic studies are necessary to establish more accurately its safety and efficacy in the goat.
Yazarlar (9)
1
Erdinc Turk
ORCID: 0000-0003-1735-1774
2
Ibrahim Ozan Tekeli
ORCID: 0000-0002-6845-2279
3
D. Durna Corum
4
Orhan Corum
ORCID: 0000-0003-3168-2510
5
Fulya Altinok Yipel
ORCID: 0000-0001-8577-2031
6
Aysun Ilhan
ORCID: 0000-0003-3491-5949
7
Sara Busra Emiroglu
ORCID: 0000-0003-0855-4967
8
Halis Uguz
ORCID: 0000-0002-9236-0630
9
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
goat
pharmacokinetics
tolfenamic acid
Kurumlar
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Hatay Mustafa Kemal
Hatay Turkey
Metrikler
10
Atıf
9
Yazar
4
Anahtar Kelime