Scopus
YÖKSİS Eşleşti
Aflatoxin B1-associated oxidative stress along with toxicopathological and immunological alterations is efficiently counteracted by dietary supplementation of distillery yeast sludge in broilers
Mycotoxin Research · Kasım 2024
YÖKSİS Kayıtları
Aflatoxin B1-associated oxidative stress along with toxicopathological and immunological alterations is efficiently counteracted by dietary supplementation of distillery yeast sludge in broilers
Mycotoxin Research · 2024 SCI-Expanded
PROFESÖR HALİS UĞUZ →
Makale Bilgileri
DergiMycotoxin Research
Yayın TarihiKasım 2024
Cilt / Sayfa40 · 615-629
Scopus ID2-s2.0-85200001223
Özet
Aflatoxin B1 (AFB1) is among the most potent genotoxic and carcinogenic mycotoxins and is a major source of distress for the growing poultry sector. On the other hand, distillery yeast sludge or distillery sludge (DS) is a byproduct of molasses-based industries. It is often treated as a waste despite containing abundant nutrients particularly protein, basic amino acids, and vitamins along with other macro and micronutrients. This study was designed to investigate the oxidative stress and immunological alterations induced by AFB1 and their amelioration by dietary supplementation with DS. For this purpose, 360 newly hatched broiler chicks were randomly divided into twelve groups (30 birds each) and fed different combinations of AFB1 (100, 200, or 600 µg/kg) and DS (5 or 10 g/kg) for 42 days. The parameters under consideration were body weight, feed conversion ratio (FCR), relative organ weights, histopathological examination of different visceral organs, total antioxidant capacity, antibody response to intravenous injection of sheep red blood cells, in situ lymphoproliferative response to phytohemagglutinin-P, and phagocytic potential through a carbon clearance assay system. The results of this study established that DS supplementation ameliorated AFB1-associated oxidative stress and ameliorated toxicopathological and immunological anomalies in groups given AFB1 at 100 µg/kg and 200 µg/kg; however, little to no relief was observed in birds fed AFB1 at 600 µg/kg. The determination of the actual ratio of the AFB1 to the DS for substantiating the ameliorating effects requires further investigation.
Yazarlar (9)
1
Aisha Khatoon
ORCID: 0000-0002-6734-4276
2
Muhammad Zargham Khan
3
Zain ul Abidin
4
Muhammad Kashif Saleemi
5
H. Oǧuz
6
Shafia Tehseen Gul
7
Rao Zahid Abbas
8
Ashiq Ali
9
Sheraz Ahmad Bhatti
Anahtar Kelimeler
AFB1
Aflatoxins
Broiler
Distillery sludge
Immunological
Mycotoxins
Oxidative stress
Toxicopathological
Yeast
Kurumlar
Bahauddin Zakariya University
Multan Pakistan
Selçuk Üniversitesi
Selçuklu Turkey
Shantou Medical Center
Shantou China
University of Agriculture, Faisalabad
Faisalabad Pakistan
Veterinary Research Institute
Lahore Cantt-13 Pakistan
Metrikler
1
Atıf
9
Yazar
9
Anahtar Kelime