Scopus
YÖKSİS Eşleşti
Cytotoxicity and genotoxicity of salicylate- and calcium silicate-based root canal sealers on primer human periodontal ligament fibroblasts
Australian Endodontic Journal · Aralık 2021
YÖKSİS Kayıtları
Cytotoxicity and genotoxicity of salicylate- and calcium
silicate-based root canal sealers on primer human periodontal
ligament fibroblasts
Australian Endodontic Journal · 2021 SCI-Expanded
PROFESÖR FUNDA KONT ÇOBANKARA →
Makale Bilgileri
DergiAustralian Endodontic Journal
Yayın TarihiAralık 2021
Cilt / Sayfa47 · 645-653
Scopus ID2-s2.0-85107323811
Özet
The aim of this study was to evaluate the biocompatibility of epoxy-resin-based AHPlus, salicylate-based MTA-Fillapex and calcium silicate-based iRootSP root canal sealers. Cytotoxicity was assessed by XTT test. The extracts from sealers of different setting times were serially diluted. Cell viability was calculated as the percentage of the control group (100%). The optimal concentration of each sealer was used at genotoxicity test, and micronuclei formations were detected. Statistical analyses were done by using Kruskal–Wallis and Dunn post hoc test with Bonferroni correction. AHPlus and MTA-Fillapex showed the lowest percentage of cell viability at higher concentrations (1:1, 1:2, 1:4), especially at first 12 h. iRootSP showed higher viability at all concentrations and times than AHPlus and MTA-Fillapex. At genotoxicity assay, AHPlus increased the number of micronuclei. MTA-Fillapex slightly induced micronucleus formation (not significant) and iRootSP was not increased. In conclusion, calcium silicate-based iRootSP had lowest cytotoxic and genotoxic potential and can be considered as a highly biocompatible material.
Yazarlar (3)
1
Hilal Erdogan
ORCID: 0000-0001-5219-4693
2
Sibel Yildirim
ORCID: 0000-0001-8044-1874
3
Funda Kont Cobankara
Anahtar Kelimeler
bioactive
biocompatibility
biomaterials
calcium silicate
cytotoxicity
genotoxicity
salicylate
Kurumlar
Nevşehir Haci Bektaş Veli Üniversitesi
Nevsehir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
10
Atıf
3
Yazar
7
Anahtar Kelime