Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Preparation of fucoidan-chitosan hydrogel and its application as burn healing accelerator on rabbits
Biological and Pharmaceutical Bulletin · Aralık 2008
YÖKSİS Kayıtları
Preparation of Fucoidan Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits
Biological & Pharmaceutical Bulletin · 2008 SCI 44 atıf
PROFESÖR AHMET LEVENT BAŞ →
Preparation of Fucoidan Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits
Biological & Pharmaceutical Bulletin · 2008 SSCI
PROFESÖR AHMET LEVENT BAŞ →
Preparation of Fucoidan Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits
Biological & Pharmaceutical Bulletin · 2008 SSCI
PROFESÖR AHMET LEVENT BAŞ →
Preparation of Fucoidan Chitosan Hydrogel and Its Application as Burn Healing Accelerator on Rabbits
Biological & Pharmaceutical Bulletin · 2008 SSCI
PROFESÖR FATİH HATİPOĞLU →
Makale Bilgileri
DergiBiological and Pharmaceutical Bulletin
Yayın TarihiAralık 2008
Cilt / Sayfa31 · 2326-2333
Scopus ID2-s2.0-57349168631
Erişim🔓 Açık Erişim
Özet
Treatment of dermal wounds with macromolecular agents such as natural polymers is one of the research areas of the biomaterial science. Fucoidan is a sulphated polysaccharide which is commonly obtained from seaweeds. The great number of studies on the different pharmacological properties of fucoidan is present, but there is limited information about using of fucoidan in the treatment of dermal burns. The aim of this study was to prepare fucoidan-chitosan hydrogels and to investigate their treatment efficiency on dermal burns. Hydrogels were prepared by swelling the polymers in acidic solution and their swelling, mechanical (hardness, cohesiveness and adhesiveness) and bioadhesive properties were investigated. The viscosity and water absorption capacity of formulations increased with increase in the polymer concentration. In contrast to the cohesiveness results, the adhesiveness of hydrogels increased with the polymer concentration. The bioadhesion was changed between 0.012-0.142 mJ·cm-2 and enhanced with addition of fucoidan into gel formulations. It was formed dermal burns on seven adult male New Zealand white rabbits and the optimum gel formulation applied on the wounds. Control and treatment group biopsy samples were taken on days 7, 14 and 21 and each burn wound site was evaluated histopathologically. No edema was seen in tested groups except control after 3 d treatment. After 7 d treatment, fibroplasia and scar were fixed on wounds treated with fucoidan-chitosan gel and fucoidan solution. The best regeneration on dermal papillary formation and the fastest closure of the wounds were observed in fucoidan-chitosan hydrogels after 14 d treatment. © 2008 Pharmaceutical Society of Japan.
Yazarlar (6)
1
A. D. Sezer
2
Erdal Cevher
3
Fatih Hatipoglu
4
Z. Ogurtan
5
A. L. Baş
6
J. Akbuga
Anahtar Kelimeler
Bioadhesion
Burn healing
Chitosan
Fucoidan
Hydrogel
Texture analyzer
Kurumlar
Istanbul Üniversitesi
Istanbul Turkey
Marmara Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
150
Atıf
6
Yazar
6
Anahtar Kelime