Scopus
YÖKSİS Eşleşti
Mesoporous silica and chitosan based pH-sensitive smart nanoparticles for tumor targeted drug delivery
Journal of Inclusion Phenomena and Macrocyclic Chemistry · Ekim 2017
YÖKSİS Kayıtları
Mesoporous silica and chitosan based pH-sensitive smart nanoparticles for tumor targeted drug delivery
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY · 2017 SCI
PROFESÖR PERVİN SOYLU →
Mesoporous silica and chitosan based pH-sensitive smart nanoparticles for tumor targeted drug delivery
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY · 2017 SCI
PROFESÖR BİLGE TANER →
Mesoporous silica and chitosan based pH-sensitive smart nanoparticles for tumor targeted drug delivery
Journal of Inclusion Phenomena and Macrocyclic Chemistry · 2017 SSCI
PROFESÖR PERVİN SOYLU →
Makale Bilgileri
DergiJournal of Inclusion Phenomena and Macrocyclic Chemistry
Yayın TarihiEkim 2017
Cilt / Sayfa89 · 15-27
Scopus ID2-s2.0-85029628186
Özet
Although various therapies have been developed for cancer treatment, chemotherapy plays a vital role, but still faces many challenges, such as severe cytotoxicity, side effects, multidrug resistance, and poor tumor selectivity. The development of targeted drug delivery has provided new strategies for addressing the limitations of the conventional chemotherapy, and has become more significant in clinical research in recent times. Among the various stimuli, pH triggered delivery is regarded as the most general strategy, targeting the acidic extracellular microenvironment and intracellular organelles of solid tumors. It is well-known that the extracellular pH of most tumor tissues is more acidic (pH 6.5–6.8) than that of normal tissues (pH 7.4). In our present review, we focus on some of the recent literature reports on the fabrication and application of pH-sensitive smart nanoparticles for tumor targeted drug delivery system. The strategies to the chemical design of these nanocarriers and their clinical findings are discussed. Particular focus is given to silica, chitosan, and silica–chitosan based nanocarriers. These smart nanoparticles will have a promising platform in improving human health and quality of life.
Yazarlar (3)
1
P. Deveci
2
B. Taner
3
Safaa Hashim Mohammed Albayati
Anahtar Kelimeler
Chitosan
Doxorubicin
Mesoporous silica
Nanoparticles
Targeted cancer therapy
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
3
Yazar
5
Anahtar Kelime