Scopus
Apoptotic effects and glucose-6-phosphate dehydrogenase responses in liver and gill tissues of rainbow trout treated with chlorpyrifos
Tissue and Cell · Aralık 2014
Makale Bilgileri
DergiTissue and Cell
Yayın TarihiAralık 2014
Cilt / Sayfa46 · 490-496
Scopus ID2-s2.0-84920002974
Özet
We investigated apoptotic effects and changes in glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in liver and gill tissues of fish exposed to chlorpyrifos. Three different chlorpyrifos doses (2.25, 4.5 and 6.75. μg/L) were administrated to rainbow trout at different time intervals (24, 48, 72 and 96. h). Acute exposure to chlorpyrifos showed time dependent decrease in G6PD enzyme activity at all concentrations (. p<. 0.05). Immunohistochemical results showed that chlorpyrifos caused mucous cell loss in gill tissue and apoptosis via caspase-3 activation in fish. The present study suggested that chlorpyrifos inhibits G6PD enzyme and causes mucous cell loss in gill and apoptosis in gill and liver tissues.
Yazarlar (5)
1
Ahmet Topal
2
Muhammed Atamanalp
3
Ertan Oruç
4
Muammer Kirici
5
Esat Mahmut Kocaman
Anahtar Kelimeler
Apoptosis
Chlorpyrifos
Gill
Glucose-6-phosphate dehydrogenase
Immunohistochemistry
Liver
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Bingöl Üniversitesi
Bingol Turkey
Metrikler
31
Atıf
5
Yazar
6
Anahtar Kelime