Scopus
YÖKSİS DOI Eşleşti
SJR Q3
The protective effects of peganum harmala extract on lung and kidney in sepsis induced by cecal ligation and perforation in rats
Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2015
YÖKSİS Kayıtları
Peganum harmala Ekstraktının Ratlarda Çekal Bağlama ve Delme ile İndüklenen Sepsiste Akciğer ve Böbrek Üzerine Koruyucu Etkileri
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2015 SSCI
Prof. Dr. ERTAN ORUÇ →
Peganum harmala Ekstraktının Ratlarda Çekal Bağlama ve Delme ile İndüklenen Sepsiste Akciğer ve Böbrek Üzerine Koruyucu Etkileri
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2015 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
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Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
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Doç. Dr. ÖZCAN ŞAHİN →
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
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2010 ISSN: 1300-6045 SCI-Expanded 5 atıf
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Türkiye’de Deney Hayvanı Kullanmaya Yetkili Kişilerin Hayvan Kullanımına Yönelik Tutumları
2015 ISSN: 1300-6045 SCI-Expanded
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Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
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Prof. Dr. HASAN GÜZELBEKTEŞ →
TheEffect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
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2015 ISSN: 1300-6045 SCI-Expanded
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2015 ISSN: 1300-6045 SCI-Expanded
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İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SSCI
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Etanersept endotoksemi tedavisinde kullanılabilir mi
2013 ISSN: 1300-6045 SCI-Expanded 2 atıf
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Makale Bilgileri
ISSN13006045
Yayın TarihiOcak 2015
Cilt / Sayfa21 · 367-375
Scopus ID2-s2.0-84923253632
Özet
Sepsis is characterized by multiple organ dysfunction, tissue damage and hyper-inflammation. Peganum harmala (PH) is a plant considered for its antibacterial, antioxidant, anticarcinogen and antiinflammatory properties. This study was aimed to evaluate the protective effects of PH extract on tissues and cytokines in sepsis induced by cecal ligation and perforation (CLP) in rats. Forty rats were divided into five groups. Groups were sham-operated (control), CLP, 90 mg/kg PH-treated CLP, 180 mg/kg PH-treated CLP and 180 mg/kg PH-treated control healthy. Animals were sacrificed at the 16th h of the study. Biochemical and histopathological analyses were performed in lung, kidney and blood samples. Both 90 mg/kg and 180 mg/kg doses of PH decreased the level of interleukin-1 beta (IL-1β) and interleukin-10 (IL-10), and high dose of PH reduced the tumor necrosis factor-alpha (TNF-α) in the serum compared to CLP group. The PH also increased the activity of superoxide dismutase (SOD) and the total levels of glutathione (GSH) in the lung and kidney tissues of septic rats. The level of malondialdehyde (MDA) in the lung and kidney tissues was reduced in both PH treated CLP groups. The histopathological results were in accordance with the biochemical results. The CLP + 180 mg/kg PH group had the lowest inflammation score in the lung. In conclusion, the administration of PH has prevented the oxidative stress, the cytokine response and the inflammation in CLP-induced septic rats.
Yazarlar (6)
1
Seçkin Özkanlar
2
Feride Koç
3
Emre Karakuş
4
Zühal Güvenalp
5
Ertan Oruç
6
Hilal Özbek
Anahtar Kelimeler
Cytokine
Inflammation
Oxidative stress
Polymicrobial sepsis
Tissue damage
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3
OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)
Metrikler
3
Atıf
6
Yazar
5
Anahtar Kelime