Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Neurotoxic effects of nickel chloride in the rainbow trout brain: Assessment of c-Fos activity, antioxidant responses, acetylcholinesterase activity, and histopathological changes
Fish Physiology and Biochemistry · Haziran 2015
YÖKSİS Kayıtları
Neurotoxic effects of nickel chloride in the rainbow trout brain Assessment of c Fos activity antioxidant responses acetylcholinesterase activity and histopathological changes
Fish Physiology and Biochemistry · 2015 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Neurotoxic effects of nickel chloride in the rainbow trout brain Assessment of c Fos activity antioxidant responses acetylcholinesterase activity and histopathological changes
2015 ISSN: 0920-1742 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Determination of hormones inducing oocyte maturation in Chalcalburnus tarichi Pallas 1811
2008 ISSN: 0920-1742 SCI-Expanded 2 atıf
Prof. Dr. ENDER ERDOĞAN →
Makale Bilgileri
ISSN09201742
Yayın TarihiHaziran 2015
Cilt / Sayfa41 · 625-634
Scopus ID2-s2.0-84939953552
Özet
The aim of this study was to determine the biochemical, immunohistochemical, and histopathological effects of nickel chloride (Ni) in the rainbow trout brain. Fish were exposed to Ni concentrations (1 mg/L and 2 mg/L) for 21 days. At the end of the experimental period, brain tissues were taken from all fish for c-Fos activity and histopathological examination and determination of acetylcholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT) enzyme activities, lipid peroxidation (LPO), and glutathione (GSH) levels. Our results showed that Ni treatment caused a significant increase in the brain SOD activity and in LPO and GSH levels (p < 0.05), but it significantly decreased AChE and CAT enzyme activities (p < 0.05). Strong induction in c-Fos was observed in some cerebral and cerebellar regions of fish exposed to Ni concentrations when compared with the control group. However, c-Fos activity was decreased in necrotic Purkinje cells. Brain tissues were characterized by demyelination and necrotic changes. These results suggested that Ni treatment causes oxidative stress, changes in c-Fos activity, and histopathological damage in the fish brain.
Yazarlar (8)
1
Ahmet Topal
2
Muhammed Atamanalp
3
Ertan Oruç
4
Mesut Bünyami Halıcı
5
Melda Şişecioğlu
6
Hüseyin Serkan Erol
7
Arzu Gergit
8
Bahar Yılmaz
Anahtar Kelimeler
Brain
c-Fos
Fish
Nickel
Oxidative stress
Toxicity
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Scimago Dergi (ISSN Eşleşmesi)
Fish Physiology and Biochemistry
Q2
SJR Skoru0,659
H-Index104
YayıncıSpringer Science and Business Media B.V.
ÜlkeNetherlands
Aquatic Science (Q2)
Biochemistry (Q2)
Medicine (miscellaneous) (Q2)
Physiology (Q3)
Metrikler
61
Atıf
8
Yazar
6
Anahtar Kelime