Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Erythropoietin hormone and ace inhibitor protect the sperm parameters of adult male rats against doxorubicin toxicity
Kafkas Universitesi Veteriner Fakultesi Dergisi · Eylül 2015
YÖKSİS Kayıtları
Eritropoietin Hormonu ve ACE İnhibitörü Erişkin Erkek Sıçanların Sperm Parametrelerini Doxorubicin Toksisitesine Karşı Korur
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2015 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
2026 ISSN: 1300-6045 SCI-Expanded
Doç. Dr. ÖZCAN ŞAHİN →
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
2026 ISSN: 1300-6045 SCI Q3
Doç. Dr. ÖZCAN ŞAHİN →
Hayvan Koruma Kavramı ve Biyoetik Çerçevesinde Yaban Hayatı Koruma ve Yaban Hayatı Geliştirme Sahaları
2012 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Anatomy of the Cervical Canal in the Angora Goat Capra hircus
2010 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. KAMİL BEŞOLUK →
Bir Ceylanda Gazella gazella Generalize Reaktif Amiloidoz Olgusu
2013 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Prevalence of Bartonella henselae in Pet and Stray Cats from the Aspect of Public Health: A Research Sample in the Concept of One Medicine - One Health
2015 ISSN: 1300-6045 SCI-Expanded Q3
Prof. Dr. MEHMET MADEN →
Fatty Acid Composition and Conjugated Linoleic Acid CLA Content of Some Commercial Milk in Turkey
2010 ISSN: 1300-6045 SCI-Expanded 5 atıf
Prof. Dr. GÖKHAN ZENGİN →
The potential of microarray databases to identify tissue specific genes
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. HİLAL ARIKOĞLU →
An Application of Bootstrap Technique in Animal Science EggYolk Color Sample
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ALİ AYGÜN →
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. RAMAZAN ÇÖL →
The Effect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
2015 ISSN: 1300-6045 SCI-Expanded Q4
Doç. Dr. ARİFE EZGİ TELLİ →
Türkiye’de Deney Hayvanı Kullanmaya Yetkili Kişilerin Hayvan Kullanımına Yönelik Tutumları
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. HASAN GÜZELBEKTEŞ →
TheEffect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ÜMİT GÜRBÜZ →
Structural and Functional Properties of the Distal Muscles ofFront and Hind Legs of Malakan Horses (Equus caballus)
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. MUSTAFA ORHUN DAYAN →
A Comparison of Different Analysis Methods for Milk Urea Nitrogen
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. MUSTAFA SELÇUK ALATAŞ →
Effects of Dietary Inactive Yeast and Live Yeast on Performance Egg Quality Traits Some Blood Parameters and Antibody Production to SRBC of Laying Hens
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. SUZAN YALÇIN →
İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SSCI
Prof. Dr. AŞKIN YAŞAR →
Etanersept endotoksemi tedavisinde kullanılabilir mi
2013 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
ISSN13006045
Yayın TarihiEylül 2015
Cilt / Sayfa21 · 805-812
Scopus ID2-s2.0-84941343493
Özet
Doxorubicin (DXR) is used against the cancer but it has some adverse effects (gonadotoxicity, cardiotoxicity and nephrotoxicity). We aimed to determine the effect of DXR toxicity on reproduction and whether Darbepoetin (DP) and Ramipril (RAM) treatments play a protective role against this toxicity in male rats. Herein, adult male Sprague-Dawley rats (n=34) were divided randomly into five groups, as control (Group I; n=7, no medication) and four treatment groups (II to V). DXR was administered to all treatment groups (DXR, 2.5 mg/kg/w i.v. for 3 weeks) and they were Group II (DXR, n=6), Group III (n=7, DP 10 μg/kg/w i.p. for three weeks), Group IV (n=7, RAM 1 mg/kg/d p.o. for four weeks), and Group V (n=7, DP+RAM). Rats in all groups were sacrificed after four weeks of treatment. Spermatological parameters along with histopathological images and malondialdehyde levels of testicular tissue were evaluated. Weights of body, testicles, cauda epididymis and male accessory glands in DXR-treated groups were significantly different (P<0.05) from the control group. DXR toxicity adversely altered all the sperm parameters. But, DP plus RAM treatment in Group V improved the DXR-depressed motility and viable sperm rate. Sperm concentrations significantly decreased (P<0.05) in DXR-treated groups as compared to control group. In Group III and V, the increase in total abnormal sperm rate caused by the DXR injections was prevented. In conclusion, this study indicated that weekly DXR injections in adult rats depressed all the epididymal sperm parameters. Co-treatment by DP and RAM protected the sperm cells against the toxicity due to the DXR administration while single usages of the DP or RAM provided partial improvements.
Yazarlar (9)
1
O. Akman
2
Yunusemre Özkanlar
3
Seçkin Özkanlar
4
Ertan Oruç
5
Nergis Ulaş
6
Tevfik Ziypak
7
Necdet Cankat Lehimcioğlu
8
Mehmet Türkeli
9
Ömer Uçar
Anahtar Kelimeler
ACE inhibitor
Doxorubicin toxication
Erythropoietin
Rat sperm
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Kafkas Üniversitesi
Kars Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3
OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)
Metrikler
8
Atıf
9
Yazar
4
Anahtar Kelime