Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
In vitro investigation of cytotoxic and apoptotic effects of Cynara L. species in colorectal cancer cells
Asian Pacific Journal of Cancer Prevention · Aralık 2013
YÖKSİS Kayıtları
In vitro Investigation of Cytotoxic and Apoptotic Effects of Cynara L Species in Colorectal Cancer Cells
Asian Pacific Journal of Cancer Prevention · 2013 SCI-Expanded
Doç. Dr. ELA NUR ŞİMŞEK SEZER →
In vitro Investigation of Cytotoxic and Apoptotic Effects of Cynara L Species in Colorectal Cancer Cells
ASIAN PACIFIC JOURNAL of CANCER PREVENTION · 2013 SCI-Expanded
Prof. Dr. TUNA UYSAL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Comparison of Metabolic and Anatomic Response to Chemotherapy Based on PERCIST and RECIST in Patients with Advanced Stage Non small Cell Lung Cancer
2015 ISSN: 1513-7368 SCI-Expanded
Prof. Dr. ORHAN ÖNDER EREN →
Importance of the Cell Block Technique in Diagnosing Patientswith Non Small Cell Carcinoma Accompanied by PleuralEffusion
2015 ISSN: 15137368 SCI-Expanded
Prof. Dr. CEYHAN UĞURLUOĞLU →
Turkish Female Academician Self Esteem and Health Beliefs for Breast Cancer Screening
2014 ISSN: 1513-7368 SCI-Expanded 6 atıf
Doç. Dr. BÜŞRA ALTINEL →
Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis
2015 ISSN: 1513-7368 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis
2015 ISSN: 1513-7368 SCOPUS
Prof. Dr. ÇETİN ÇELİK →
Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis
2015 ISSN: 1513-7368 medicus, medline,pubmed
Prof. Dr. SETENAY ARZU YILMAZ →
Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis
2015 ISSN: 1513-7368 SCI-Expanded
Prof. Dr. AYBİKE PEKİN →
Mean Platelet Volume Could be a Possible Biomarker for Papillary Thyroid Carcinomas
2015 ISSN: 1513-7368 SCOPUS, PUBMED, INDEX COPERNICUS, EMBASE
Prof. Dr. SÜLEYMAN BALDANE →
Positive Effects of Oral Glucan on Mucositis and Leukopenia in Colorectal Cancer Patients Receiving Adjuvant FOLFOX 4 Combination Chemotherapy
2014 ISSN: 1513-7368 SCI-Expanded
Prof. Dr. SÜLEYMAN BALDANE →
Fentanyl Inhibits Tumorigenesis from Human Breast Stem Cells by Inducing Apoptosis
2017 ISSN: 1513-7368 Sağlık, Tıp
Doç. Dr. NADİR KOÇAK →
Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis
2015 ISSN: 1513-7368 scopus, IC, ISI, Cite factor, MEDLİNE/PubMed, EMBASE, DOAJ
Prof. Dr. ÇETİN ÇELİK →
Fentanyl Inhibits Tumorigenesis from Human Breast Stem Cells by Inducing Apoptosis
2017 ISSN: 1513-7368 MEDLINE/PubMed
Doç. Dr. NADİR KOÇAK →
In vitro Investigation of Cytotoxic and Apoptotic Effects of Cynara L Species in Colorectal Cancer Cells
2013 ISSN: 1513-7368 SCI-Expanded Q4
Doç. Dr. ELA NUR ŞİMŞEK SEZER →
Treatment Outcomes and Survival Study of Gastric Cancer Patients: A Retrospective Analysis in an Endemic Region
2015 ISSN: 1513-7368 PUBMED
Doç. Dr. HAMİT BAŞARAN →
Dietary and Demographical Risk Factors for Oesophageal Squamous Cell Carcinoma in the Eastern Anatolian Region of Turkey Where Upper Gastrointestinal Cancers are Endemic
2015 ISSN: 1513-7368 SCI-Expanded
Doç. Dr. HAMİT BAŞARAN →
Comparison of Linear Accelerator and Helical Tomotherapy Plans for Glioblastoma Multiforme Patients
2014 ISSN: 1513-7368 SCI-Expanded Q3
Doç. Dr. HAMİT BAŞARAN →
Impact of Poster Presentations on Academic Knowledge Transfer from the Oncologist Perspective in Turkey
2014 ISSN: 1513-7368 SCI-Expanded
Doç. Dr. HAMİT BAŞARAN →
Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis
2015 ISSN: 1513-7368 index copernicus, SCOPUS, DOAJ, EMBASE
Prof. Dr. ÇETİN ÇELİK →
Dietary and Demographical Risk Factors for Oesophageal Squamous Cell Carcinoma in the Eastern Anatolian Region of Turkey Where Upper Gastrointestinal Cancers are Endemic
2015 ISSN: 1513-7368 SCOPUS, INDEX COPERNICUS
Doç. Dr. HAMİT BAŞARAN →
Adjuvant Chemotherapy and Prognostic Factors in Stage II Colon Cancer - Izmir Oncology Group Study
2015 ISSN: 1513-7368 scopus
Dr. Öğr. Üyesi SERKAN YILDIRIM →
Makale Bilgileri
ISSN15137368
Yayın TarihiAralık 2013
Cilt / Sayfa14 · 6791-6795
Scopus ID2-s2.0-84892458617
Erişim🔓 Açık Erişim
Özet
Apoptotic and cytotoxic activity of plant extracts obtaining from naturally growing Cynara syriaca in Turkey and cultivated C cardunculus against DLD1 colorectal cancer cells was determined. Extracts from wild and cultivated Cynara species were obtained from their vegetative parts and receptacles using hexane and applied with five different dose (0.1-1 mg/ml) as well as apigenin for MTT tests for three time periods (24, 48 and 72 hours). After cells were treated with IC50 doses for each extract total DNA and RNA were isolated for determination of the cause of cell death. From isolated RNAs, cDNA were synthesized and amplification of p21, BCL-2 and BAX gene regions was carried out. Consequently, we found that pro-apoptotic (BAX) gene expression and a cell cycle inhibitor (p21) were induced in the presence of our artichoke extracts. In contrast, anti-apoptotic BCL-2 gene expression was reduced compared to the control group. In addition DNA fragmentation results demonstrated DLD1 cell death via apoptosis.
Yazarlar (2)
1
Ela Nur Simsek
2
Tuna Uysal
Anahtar Kelimeler
Anti-cancer agent
Artichoke
CDNA
Colorectal cancer
DLD1
DNA fragmentation
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Asian Pacific Journal of Cancer Prevention
Q2
OA
SJR Skoru0,530
H-Index98
YayıncıAsian Pacific Organization for Cancer Prevention
ÜlkeThailand
Public Health, Environmental and Occupational Health (Q2)
Epidemiology (Q3)
Oncology (Q3)
Cancer Research (Q4)
Metrikler
27
Atıf
2
Yazar
6
Anahtar Kelime