Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Assessment of antimutagenic action of Celtis glabrata Steven ex Planch. (Cannabaceae) extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test
Drug and Chemical Toxicology · Temmuz 2016
YÖKSİS Kayıtları
Assessment of Antimutagenic Action of Celtis glabrata Steven ex Planch Cannabaceae Extracts Against Base Pair Exchange and Frame Shift Mutations on Salmonella typhimurium TA98 and TA100 Strains by Ames Test
DRUG AND CHEMICAL TOXICOLOGY · 2016 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Assessment of antimutagenic action of Celtis glabrata Steven ex Planch Cannabaceae extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test
Drug and Chemical Toxicology · 2016 SCI-Expanded
Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Assessment of Antimutagenic Action of Celtis glabrata Steven ex Planch Cannabaceae Extracts Against Base Pair Exchange and Frame Shift Mutations on Salmonella typhimurium TA98 and TA100 Strains by Ames Test
2016 ISSN: 0148-0545 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Alterations of blood parameters after intramuscular administration of imidocarb in healthy lambs
2012 ISSN: 0148-0545 SCI-Expanded
Prof. Dr. NERMİN IŞIK USLU →
Assessment of antimutagenic action of Celtis glabrata Steven ex Planch Cannabaceae extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test
2016 ISSN: 0148-0545 SCI-Expanded
Dr. Öğr. Üyesi ERDOĞAN GÜNEŞ →
Assessment of antimutagenic action of Celtis glabrata Steven ex Planch Cannabaceae extracts against base pair exchange and frame shift mutations on Salmonella typhimurium TA98 and TA100 strains by Ames test
2016 ISSN: 0148-0545 SSCI
Prof. Dr. MUSTAFA ONUR ALADAĞ →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q3
Prof. Dr. NADİRE ÜNVER DOĞAN →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. HASAN ACAR →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2021 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Lipid-lowering, anti-inflammatory, and hepatoprotective effects of isorhamnetin on acetaminophen-induced hepatotoxicity in mice
2023 ISSN: 0148-0545 SCI-Expanded Q2
Doç. Dr. MEHMET BURAK ATEŞ →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. AHMET KAĞAN KARABULUT →
In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
2022 ISSN: 0148-0545 SCI-Expanded Q2
Prof. Dr. NADİRE ÜNVER DOĞAN →
The neuroprotective effect of 1,25-dyhydroxyvitamin D3 (calcitriol) and probiotics on the rotenone-induced neurotoxicity model in SH-SY5Y cells
2025 ISSN: 0148-0545 SCI-Expanded Q3
Dr. Öğr. Üyesi FATMA HAZAN DOĞAN →
Makale Bilgileri
ISSN01480545
Yayın TarihiTemmuz 2016
Cilt / Sayfa39 · 312-321
Scopus ID2-s2.0-84953210352
Özet
Context: Celtis glabrata is used in Turkey for the treatment of various health disorders. Objective: The acetone, chloroform, ethanol, and methanol extracts of C. glabrata leaf, fruit, and seed were investigated to evaluate their antimutagenic activities. Material and methods: The antimutagenicity of these extracts was determined by Ames test against mutagens (4-nitro-O-phenylenediamine, 2-aminofluorene (2-AF), and sodium azide (SA)). The extracts were used at concentrations between 5 and 0.005 mg/plate. Results: The ethanol extracts of leaves exhibited strong antimutagenicity (70%) against 2-AF with S9 at 5 mg/plate on TA98. But methanol (61%, 53%) and acetone (53%, 52%) also revealed strong inhibition rates at concentrations of ≥0.5 mg/plate. Among the extracts, the highest activity (96%) was obtained from acetone extract against SA without S9, followed by chloroform extract (91%) at a dose of 5 mg/plate on TA100 with S9. Ethanol (without S9) and chloroform (with S9) extracts showed strong antimutagenicity at all doses. Exception of chloroform and acetone (without S9), all fruit extracts (with/without S9) manifested strong antimutagenicity at doses of ≥0.5 mg/plate on TA98 strain. Ethanol extracts revealed 68% inhibition against 2-AF on TA98. Acetone and ethanol extracts manifested 84% and 82% inhibition against SA on TA100, respectively. All the extracts of seeds revealed strong inhibition against 2-AF at ≥0.5 mg/plate doses on TA98, but acetone extract showed excellent antimutagenicity (94%). Moreover, the chloroform (74, 73, 63, 54%), acetone (74, 72, 70, 65%) and methanol (74, 67, 63, 61%) extracts of seeds revealed strong antimutagenic activity on TA100 against SA with S9. Discussion and conclusion: This plant may be natural source of antimutagenic agents.
Yazarlar (5)
1
Duygu Akın
2
Yusuf Durak
3
Ahmet Uysal
4
Erdogan Gunes
5
Mustafa Onur Aladag
Anahtar Kelimeler
antimutagenicity
Cannabaceae
free radical scavenging
Salmonella/microsome test system
total phenol content
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Drug and Chemical Toxicology
Q2
SJR Skoru0,535
H-Index60
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q2)
Public Health, Environmental and Occupational Health (Q2)
Chemical Health and Safety (Q3)
Health, Toxicology and Mutagenesis (Q3)
Pharmacology (Q3)
Toxicology (Q3)
Metrikler
11
Atıf
5
Yazar
5
Anahtar Kelime