Scopus
YÖKSİS Eşleşti
Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications
Phytomedicine · Eylül 2016
YÖKSİS Kayıtları
Chemical and biological insights on Cotoneaster integerrimus A new epicatechin source for food and medicinal applications
Phytomedicine · 2016 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ ERDOĞAN GÜNEŞ →
Chemical and biological insights on Cotoneaster integerrimus A new epicatechin source for food and medicinal applications
Phytomedicine · 2016 SCI
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Chemical and Biological Insights on Cotoneaster integerrimus A new epicatechin source for food and medicinal applications
Phytomedicine · 2016 SCI-Expanded
PROFESÖR AHMET UYSAL →
Makale Bilgileri
DergiPhytomedicine
Yayın TarihiEylül 2016
Cilt / Sayfa23 · 979-988
Scopus ID2-s2.0-84978033462
Özet
Background The Cotoneaster species are widely used as traditional purposes in different countries including Turkey. Purpose The study was performed to evaluate the biological and chemical profile of two extracts (methanol (T-Me; F-Me) and water (T-W; F-W)) from two parts (twigs and fruits) of Cotoneaster integerrimus. Materials and methods Antioxidant (free radical scavenging (DPPH), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating), enzyme inhibitory (cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial (standard microorganisms and methicillin-resistant Staphylococcus aureus isolates (MRSA)) and mutagenic/antimutagenic effects (by Ames assay) were tested for biological profile. For chemical profile, total and individual phenolic components were detected for each extract. Results Generally, T-Me reflected the strongest biological effects with the highest level of phenolics (115. 15 mgGAEs/g extract). Also, twig extracts had more potent biological effects as compared to flower extracts. Eight-teen phenolics were identified in the extracts. (-)- epicatechin was the major constituent in all extracts and is mainly responsible for biological activities observed. Its amount present in F-W and T-W were 9.27 and 32.89 mg/g extract, respectively. Also, molecular docking was used to understand enzyme-epicatechin interactions. Conclusion From these results, this plant has a great potential as a health promoter for developing novel functional food ingredients and pharmaceutical preparations.
Yazarlar (7)
1
Ahmet Uysal
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Adriano Mollica
4
Erdogan Gunes
5
Marcello Locatelli
ORCID: 0000-0002-0840-825X
6
Turgut Yilmaz
7
Abdurrahman Aktumsek
Anahtar Kelimeler
Biological effect
Chemical fingerprint
Cotoneaster
(-)-epicatechin
Molecular docking
Nutraceuticals
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Interuniversity Consortium of Structural and Systems Biology
Rome Italy
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Metrikler
60
Atıf
7
Yazar
6
Anahtar Kelime