Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations
Biomedicine and Pharmacotherapy · Mart 2017
YÖKSİS Kayıtları
Euphorbia denticulata Lam A promising source of phyto pharmaceuticals for the development of novel functional formulations
Biomedicine Pharmacotherapy · 2017 SCI
Prof. Dr. AHMET UYSAL →
Euphorbia denticulata Lam A promising source of phyto pharmaceuticals for the development of novel functional formulations
Biomedicine Pharmacotherapy · 2017 SCI
Prof. Dr. GÖKHAN ZENGİN →
Euphorbia denticulata Lam A promising source of phyto pharmaceuticals for the development of novel functional formulations
Biomedicine Pharmacotherapy · 2017 SCI
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Femtosecond Laser Induced Photodynamic Therapy on 5-ALA Treated SKMEL-30 Cells: An Efficient Theranostic Strategy to Combat Melanoma
2014 ISSN: 0753-3322 SCI-Expanded 3 atıf
Öğr. Gör. REYHAN KARA →
Celecoxib administration reduced mortality mesenteric hypoperfusion aortic dysfunction and multiple organ injury in septic rats
2017 ISSN: 07533322 SCI-Expanded
Prof. Dr. CEYHAN UĞURLUOĞLU →
Euphorbia denticulata Lam A promising source of phyto pharmaceuticals for the development of novel functional formulations
2017 ISSN: 07533322 SCI
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Coenzyme Q10 improves the survival, mesenteric perfusion, organs and vessel functions in septic rats
2017 ISSN: 07533322 SCI
Prof. Dr. CEYHAN UĞURLUOĞLU →
Multiple pharmacological targets, cytotoxicity, and phytochemical profile of Aphloia theiformis (Vahl.) Benn.
2017 ISSN: 07533322 SCI
Prof. Dr. GÖKHAN ZENGİN →
Anti-hyperalgesic effect of Lippia grata leaf essential oil complexed with β-cyclodextrin in a chronic musculoskeletal pain animal model: Complemented with a molecular docking and antioxidant screening
2017 ISSN: 07533322 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Femtosecond laser induced photodynamic therapy on 5-ALA treated SKMEL-30 cells: An efficient theranostic strategy to combat melanoma
2014 ISSN: 0753-3322 SCI-Expanded Q3
Doç. Dr. YASEMİN GÜNDOĞDU KABAKCI →
In vivo and in silico sedative-hypnotic like activity of 7-methyljuglone isolated from Diospyros lotus L.
2017 ISSN: 0753-3322 SCI
Prof. Dr. GÖKHAN ZENGİN →
Microbiota alteration and modulation in Alzheimer's disease by gerobiotics: The gut-health axis for a good mind
2022 ISSN: 0753-3322 SCI-Expanded Q1
Dr. Öğr. Üyesi OSMAN BOZKURT →
Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic
dysfunction and multiple organ injury in septic rats
2016 ISSN: 0753-3322 SCI-Expanded
Prof. Dr. CEYHAN UĞURLUOĞLU →
Makale Bilgileri
ISSN07533322
Yayın TarihiMart 2017
Cilt / Sayfa87 · 27-36
Scopus ID2-s2.0-85007433729
Özet
In this study, Methanolic extracts of Euphorbia denticulata parts (flowers, leaf, stem, and mix of aerial parts) were assessed for a panoply of bioactivities. Inhibitory potential against key enzymes involved in diabetes (α-glucosidase and α-amylase), obesity (pancreatic lipase), neurodegenerative diseases (cholinesterases), and hyperpigmentation (tyrosinase) was evaluated. The antioxidant and antibacterial properties were also assessed. The total phenolic, flavonoid, and phytochemical profile were established using HPLC/DAD and molecular modelling studies on specific target compounds were performed in silico. The flower extract was found to be rich in phenolics and flavonoids, (60.11 ± 1.40 mgGAE/g and 42.04 ± 0.16 mgRE/g respectively), which tend to correlate with the high radical scavenging activity of this extract (120.34 ± 3.33 mgTE/g and 165.42 ± 2.16 mgTE/g for DPPH and ABTS respectively). Catechin, epicatechin, gallic acid, p-OH-Benzoic acid, rosmarinic acid, and epigallocatechin gallate, found in significant abundance in the extracts were assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. The extracts were moderately effective with MIC values ranging between 1.56 to 6.25 mg/ml, but potent growth inhibitors of MRSA strains. Results amassed herein can be used as a stimulus for further studies geared towards the development of novel phyto-pharmaceuticals.
Yazarlar (11)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Ahmet Uysal
3
Abdurrahman Aktumsek
4
Andrei Mocan
5
Adriano Mollica
6
Marcello Locatelli
ORCID: 0000-0002-0840-825X
7
Luisa Custodio
8
Nuno R. Neng
9
José M.F. Nogueira
10
Zaahira Aumeeruddy-Elalfi
11
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Diabetes
Euphorbia denticulata
Molecular docking
Phyto-pharmaceuticals
Polyphenols
Kurumlar
Faculdade de Ciências da Universidade de Lisboa
Lisbon Portugal
Selçuk Üniversitesi
Selçuklu Turkey
Universidade do Algarve
Faro Portugal
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Cluj Napoca Romania
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Scimago Dergi (ISSN Eşleşmesi)
Biomedicine and Pharmacotherapy
Q1
OA
SJR Skoru1,775
H-Index169
YayıncıElsevier Masson s.r.l.
ÜlkeFrance
Medicine (miscellaneous) (Q1)
Pharmacology (Q1)
Metrikler
86
Atıf
11
Yazar
5
Anahtar Kelime