Scopus
YÖKSİS Eşleşti
Euphorbia denticulata Lam.: A promising source of phyto-pharmaceuticals for the development of novel functional formulations
Biomedicine and Pharmacotherapy · Mart 2017
YÖKSİS Kayıtları
Euphorbia denticulata Lam A promising source of phyto pharmaceuticals for the development of novel functional formulations
Biomedicine Pharmacotherapy · 2017 SCI
PROFESÖR AHMET UYSAL →
Euphorbia denticulata Lam A promising source of phyto pharmaceuticals for the development of novel functional formulations
Biomedicine Pharmacotherapy · 2017 SCI
PROFESÖR GÖKHAN ZENGİN →
Euphorbia denticulata Lam A promising source of phyto pharmaceuticals for the development of novel functional formulations
Biomedicine Pharmacotherapy · 2017 SCI
PROFESÖR ABDURRAHMAN AKTÜMSEK →
Makale Bilgileri
DergiBiomedicine and Pharmacotherapy
Yayın TarihiMart 2017
Cilt / Sayfa87 · 27-36
Scopus ID2-s2.0-85007433729
Özet
In this study, Methanolic extracts of Euphorbia denticulata parts (flowers, leaf, stem, and mix of aerial parts) were assessed for a panoply of bioactivities. Inhibitory potential against key enzymes involved in diabetes (α-glucosidase and α-amylase), obesity (pancreatic lipase), neurodegenerative diseases (cholinesterases), and hyperpigmentation (tyrosinase) was evaluated. The antioxidant and antibacterial properties were also assessed. The total phenolic, flavonoid, and phytochemical profile were established using HPLC/DAD and molecular modelling studies on specific target compounds were performed in silico. The flower extract was found to be rich in phenolics and flavonoids, (60.11 ± 1.40 mgGAE/g and 42.04 ± 0.16 mgRE/g respectively), which tend to correlate with the high radical scavenging activity of this extract (120.34 ± 3.33 mgTE/g and 165.42 ± 2.16 mgTE/g for DPPH and ABTS respectively). Catechin, epicatechin, gallic acid, p-OH-Benzoic acid, rosmarinic acid, and epigallocatechin gallate, found in significant abundance in the extracts were assessed using molecular modelling with the aim to study their docking properties on a set of six enzymes used in this study. The extracts were moderately effective with MIC values ranging between 1.56 to 6.25 mg/ml, but potent growth inhibitors of MRSA strains. Results amassed herein can be used as a stimulus for further studies geared towards the development of novel phyto-pharmaceuticals.
Yazarlar (11)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Ahmet Uysal
3
Abdurrahman Aktumsek
4
Andrei Mocan
5
Adriano Mollica
6
Marcello Locatelli
ORCID: 0000-0002-0840-825X
7
Luisa Custodio
8
Nuno R. Neng
9
José M.F. Nogueira
10
Zaahira Aumeeruddy-Elalfi
11
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Diabetes
Euphorbia denticulata
Molecular docking
Phyto-pharmaceuticals
Polyphenols
Kurumlar
Faculdade de Ciências da Universidade de Lisboa
Lisbon Portugal
Selçuk Üniversitesi
Selçuklu Turkey
Universidade do Algarve
Faro Portugal
Universitatea de Medicina si Farmacie Iuliu Hatieganu din Cluj-Napoca
Cluj Napoca Romania
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Metrikler
80
Atıf
11
Yazar
5
Anahtar Kelime