Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Multicomponent pattern and biological activities of seven Asphodeline taxa: Potential sources of natural-functional ingredients for bioactive formulations
Journal of Enzyme Inhibition and Medicinal Chemistry · Ekim 2017
YÖKSİS Kayıtları
Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations
Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations
Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations
Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of 3 aroyl 4 aryl 1 isopropylamino 4 piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
2014 ISSN: 1475-6366 SCI
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis of 4 2 substituted hydrazinyl benzenesulfonamides and their carbonic anhydrase inhibitory effects
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Anthraquinone profile antioxidant and enzyme inhibitory effect of root extracts of eight i Asphodeline i taxa from Turkey can i Asphodeline i roots be considered as a new source of natural compounds title
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Multicomponent pattern and biological activities of seven Asphodeline taxa: potential sources of natural-functional ingredients for bioactive formulations
2017 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. AHMET UYSAL →
Comparative study of biological activities and multicomponent pattern of two wild Turkish species: Asphodeline anatolica and Potentilla speciosa
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic
<i>Thymus spathulifolius</i>
Hausskn. et Velen
</title>
2016 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Microwave-assisted synthesis and bioevaluation of new sulfonamides
2017 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. KAAN KÜÇÜKOĞLU →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
2020 ISSN: 1475-6366 SCI-Expanded
Prof. Dr. MUSTAFA YILMAZ →
Antioxidant activity of indole-based melatonin analogues in erythrocytes and their voltammetric characterization
2013 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities
2016 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Synthesis and evaluation of antioxidant activity of new quinoline-2-carbaldehyde hydrazone derivatives: bioisosteric melatonin analogues
2016 ISSN: 1475-6366 SCI
Doç. Dr. HANİF ŞİRİNZADE →
Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action
2020 ISSN: 1475-6366 SCI-Expanded Q1
Doç. Dr. MEHMET OĞUZ →
Makale Bilgileri
ISSN14756366
Yayın TarihiEkim 2017
Cilt / Sayfa32 · 60-67
Scopus ID2-s2.0-84992199659
Erişim🔓 Açık Erişim
Özet
The current study was carried out to evaluate multicomponent pattern, biological and enzymatic activities of seven Asphodeline taxa root extracts as useful ingredients, due to the fact that these plants are commonly used as traditional food supplements in Turkish regions. The extracts were characterized for free anthraquinones and phenolics to obtain a specific chemical fingerprint useful for quality control. These analyzes were coupled to biological and enzymatic activities in order to obtain comprehensive information of the natural product. Free anthraquinones and phenolics were determined using validated HPLC-PDA methods. Antioxidant properties were determined by different procedures including free radical scavenging, reducing power, phosphomolybdenum and metal chelating assays. Ames assay was performed to evaluate mutagenic/antimutagenic properties. Enzyme inhibitory activities were tested against cholinesterase, tyrosinase, a-amylase and a-glucosidase. From the herein reported results, Asphodeline could be valuable for the production of bioactive products or food supplements for cosmetic and pharmaceutical industries. List of abbreviations: ABTS: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); AChE: acetylcholinesterase; ADD: A. damascena subsp. damascena; ADG: A. damascena subsp. gigantea; ADO: A. damascena subsp. ovoidea; ADR: A. damascena subsp. rugosa; APR: A. prismatocarpa; ATT: A. tenuior subsp. tenuiflora var. tenuiflora; ATU: A. turcica; BChE: butyrylcholinesterase; CUPRAC: cupric ion reducing; DPPH: 2,2-diphenyl-1-picrylhydrazyl; en: endemic; FDA: Food and Drug Administration; FRAP: ferric ion reducing antioxidant power; GAE: gallic acid equivalents; HPLC-PDA: high performance liquid chromatography - photodiode array detector; RE: rutin equivalents; TE: trolox equivalents.
Yazarlar (8)
1
Marcello Locatelli
ORCID: 0000-0002-0840-825X
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Ahmet Uysal
4
Simone Carradori
5
Elisa De Luca
6
Giuseppe Bellagamba
7
Abdurrahman Aktumsek
8
Irina Lazarova
Anahtar Kelimeler
Anthraquinones
Asphodeline
Biological activity and bioactive compounds
Multicomponent pattern
Phenolics
Kurumlar
Interuniversity Consortium of Structural and Systems Biology
Rome Italy
Medical University of Sofia
Sofia Bulgaria
Selçuk Üniversitesi
Selçuklu Turkey
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
Scimago Dergi (ISSN Eşleşmesi)
Journal of Enzyme Inhibition and Medicinal Chemistry
Q2
OA
SJR Skoru0,857
H-Index98
YayıncıInforma Healthcare
ÜlkeUnited Kingdom
Drug Discovery (Q2)
Medicine (miscellaneous) (Q2)
Pharmacology (Q2)
Metrikler
71
Atıf
8
Yazar
5
Anahtar Kelime