Scopus
YÖKSİS Eşleşti
Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight
Journal of Pharmaceutical and Biomedical Analysis · Ekim 2018
YÖKSİS Kayıtları
Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2018 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ ERDOĞAN GÜNEŞ →
Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2018 SCI-Expanded
PROFESÖR GÖKHAN ZENGİN →
Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2018 SCI
PROFESÖR GÖKHAN ZENGİN →
Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS · 2018 SCI
PROFESÖR AHMET UYSAL →
Makale Bilgileri
DergiJournal of Pharmaceutical and Biomedical Analysis
Yayın TarihiEkim 2018
Cilt / Sayfa160 · 374-382
Scopus ID2-s2.0-85051650887
Özet
The inhibitory action of F. halophila extracts (acetone, chloroform, and methanol) against key enzymes linked to diabetes (α-amylase, α-glucosidase), cognitive functions (acetyl cholinesterase (AChE), butyryl cholinesterase (BChE)), and hyperpigmentation (tyrosinase) was assessed. The mutagenic/antimutagenic activities were assessed and the phytochemical profile established by HPLC-MS/MS. The acetone extract showed the highest phenolic (55.22 mg GAE/g extract) and flavonoid (34.52 mg RE/g extract) contents. The chloroform extract was a potent inhibitor of cholinesterases (4.86 and 6.13 mg GALAE/g extract, against AChE and BChE, respectively). Cinnamic acid derivatives (methyl cinnamate, ferulic acid, methoxycinnamic acid isomer) were identified in the chloroform extract. Methanol extract showed potent inhibitory action against tyrosinase (137.63 mg KAE/g extract) and glucosidase (43.02 mmol ACAE/g extract). The chloroform extract (32.07 mg EDTAE/g extract) showed potent metal chelating potential. The neuroprotective action of the chloroform extract might be attributed to the metal chelating action coupled by the cholinesterase inhibitory potential. F. halophila showed no mutagenic capacity. When combined with 2-aminoflouren and 2-aminoanthracene, the acetone and chloroform extracts revealed excellent antimutagenicity in the presence of metabolic activation enzymes for Salmonella typhimurium TA98 and TA100 strains. The observed inhibitory effects of F. halophila against the studied enzyme suggest that this plant could be a promising source of bioactive phytochemicals for the management of clinical conditions.
Yazarlar (8)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Ahmet Uysal
3
Alina Diuzheva
ORCID: 0000-0003-2090-1634
4
Erdogan Gunes
5
József Jekő
6
Zoltán Cziáky
7
Carene Marie Nancy Picot-Allain
8
Mohamad Fawzi Mahomoodally
Anahtar Kelimeler
Biological potential
Ferula
Medicinal values
mutagenic/antimutagenic activities
Natural agents
Phenolics
Kurumlar
Pavol Jozef Šafárik University in Košice
Kosice Slovakia
Selçuk Üniversitesi
Selçuklu Turkey
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
Metrikler
65
Atıf
8
Yazar
6
Anahtar Kelime