Scopus
YÖKSİS DOI Eşleşti
SJR Q1
If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products
Industrial Crops and Products · Şubat 2020
YÖKSİS Kayıtları
If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products
INDUSTRIAL CROPS AND PRODUCTS · 2020 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products
INDUSTRIAL CROPS AND PRODUCTS · 2020 SCI-Expanded
Prof. Dr. AHMET UYSAL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer skin diseases and type II diabetes
2014 ISSN: 09266690 SCI-Expanded 4 atıf
Prof. Dr. GÖKHAN ZENGİN →
HPLC DAD analysis of phenolic compounds and antioxidant properties of Asphodeline lutea roots from Bulgaria and Turkey
2014 ISSN: 09266690 SCI-Expanded 1 atıf
Prof. Dr. GÖKHAN ZENGİN →
Phenolic constituent antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L from Turkey A phytochemical study
2015 ISSN: 09266690 SCI-Expanded 1 atıf
Prof. Dr. GÖKHAN ZENGİN →
Composition antioxidant antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies subsp vulgare and subsp hirtum essential oils
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Changes in the fatty acid compositions and bioactivities of clary sage seeds depending on harvest year
2012 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. ERAY TULUKCU →
A phytochemical study on Potentilla anatolica An endemic Turkish plant
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Phenolic constituent antioxidative and tyrosinase inhibitory activity of Ornithogalum narbonense L from Turkey A phytochemical study
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Composition antioxidant antimicrobial and enzyme inhibition activities of two Origanum vulgare subspecies subsp vulgare and subsp hirtum essential oils
2015 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
HPLC DAD analysis of phenolic compounds and antioxidant properties of Asphodeline lutea roots from Bulgaria and Turkey
2014 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer skin diseases and type II diabetes
2014 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Chemical and biological fingerprints of two Fabaceae species Cytisopsis dorycniifolia and Ebenus hirsuta Are they novel sources of natural agents for pharmaceutical and food formulations
2016 ISSN: 09266690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A study on in vitro enzyme inhibitory properties of Asphodeline anatolica New sources of natural inhibitors for public health problems
2016 ISSN: 09266690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Immunomodulatory properties of various natural compounds and essential oils through modulation of human cellular immune response
2016 ISSN: 09266690 SCI
Prof. Dr. YÜKSEL KAN →
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
2018 ISSN: 09266690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
HPLC–MS/MS-based metabolic profiling and pharmacological properties of extracts and infusion obtained from Amelanchier parviflora var. dentata
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Enzyme inhibitory and antioxidant activities of Nerium oleander L. flower extracts and activity guided isolation of the active components
2018 ISSN: 0926-6690 SCI-Expanded Q1
Prof. Dr. GÖKHAN ZENGİN →
Bioactivity-guided isolation of cytotoxic secondary metabolites from the roots of Glycyrrhiza glabra and elucidation of their mechanisms of action
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. YÜKSEL KAN →
Lotus aegaeus (Gris.) Boiss and Iberis sempervirens L.: Chemical fingerprints, antioxidant potential, and inhibition activities and docking on key enzymes linked to global health problems
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Exploring the therapeutic potential and phenolic composition of two Turkish ethnomedicinal plants – Ajuga orientalis L. and Arnebia densiflora (Nordm.) Ledeb.
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey
2018 ISSN: 0926-6690 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Makale Bilgileri
ISSN09266690
Yayın TarihiŞubat 2020
Cilt / Sayfa144
Scopus ID2-s2.0-85075856493
Özet
The halophyte species Carpobrotus edulis (L.) N.E. Br, also known as Hottentot-fig, is one of the 20 most aggressive invasive species of coastal areas worldwide. It is native to South Africa, where it is used in traditional medicine for the treatment of several diseases, including tuberculosis and acquired immunodeficiency syndrome (AIDS) caused by the human immunodeficiency virus (HIV). Aiming at a sustainable use of its biomass as a value-added product, this work reports for the first time the in vitro antioxidant, anti-microbial, enzymatic inhibitory properties and toxicity of peel and flesh extracts of Hottentot-fig mature fruits. The extracts’ chemical composition was also determined by spectrophotometric methods (total contents of phenolics: TPC; flavonoids: TFC and tannins: TTC), and by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS/MS). The peels’ extracts had generally the highest TPC, TFC and TTC, especially the ethanol ones (TPC: 272.82 mg gallic acid equivalents (GAE)/g dry weight (DW), TFC: 1.58 mg quercetin equivalents (QE)/g DW and TTC: 20.3 mg catechin equivalents (CE)/g DW). The peels’ extracts also had the highest diversity of compounds, mostly phenolic acids, flavonoids, and coumarins, as identified by HPLC-ESI-MS/MS. Some molecules were specific to a particular fruit part, for example, coumaric acid and uvaol in the peel, and vanillin and kaempferol-O-(rhamnosyl)hexosylhexoside in the flesh. Some compounds are here described for the first time in Hottentot-fig, s uch as azelaic acid and emodin. The peel´s extracts had the highest anti radical activity, especially the ethanol and acetone towards 2,2-diphenyl-1-picrylhydrazyl (DPPH) (half maximal inhibitory concentration (IC50) values of 0.59 and 0.88 mg/mL, respectively), and the acetone extract against 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) (IC50 = 0.56 mg/mL). Samples had nil capacity to chelate iron, a low copper chelation potential, but a significant capacity to reduce iron, especially the ethanol (IC50 = 0.09 mg/mL) and the acetone extracts of peels (IC50 = 0.10 mg/mL) and flesh (IC50 = 0.11 mg/mL) and also the water peel's extracts (IC50 = 0.18 mg/mL). Samples had nil to low activity towards the enzymes acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), α-amylase and α-glucosidase, but displayed a strong inhibition of tyrosinase, especially the ethanol peel's extracts (29.55 mg kojic acid equivalents (KAE)/g). Samples had nil to low in vitro toxicity towards human keratinocytes. All together our results suggests possible novel biotechnological applications of Hottentot-fig fruits as sources of innovative bioactive ingredients for the food, cosmetic, agriculture and/or pharmaceutical industries.
Yazarlar (11)
1
Viana Castañeda-Loaiza
ORCID: 0000-0002-8839-1389
2
Chloé Placines
3
Maria João Rodrigues
4
Catarina Pereira
ORCID: 0000-0002-1131-8773
5
Gokhan Zengin
ORCID: 0000-0001-6548-7823
6
Ahmet Uysal
7
József Jekő
8
Zoltán Cziáky
9
Catarina Pinto Reis
ORCID: 0000-0002-1046-4031
10
Maria Manuela Gaspar
11
Luisa Custodio
Anahtar Kelimeler
Enzyme inhibitors
Hottentot-fig
Hyperpigmentation
Invasive species
Oxidative stress
Salt tolerant plants
Kurumlar
Faculdade de Farmácia da Universidade de Lisboa
Lisbon Portugal
Selçuk Üniversitesi
Selçuklu Turkey
Universidade de Lisboa
Lisbon Portugal
Universidade do Algarve
Faro Portugal
University of Nyíregyháza
Nyíregyháza Hungary
Scimago Dergi (ISSN Eşleşmesi)
Industrial Crops and Products
Q1
SJR Skoru0,974
H-Index186
YayıncıElsevier B.V.
ÜlkeNetherlands
Agronomy and Crop Science (Q1)
Metrikler
26
Atıf
11
Yazar
6
Anahtar Kelime