Scopus
🔓 Açık Erişim
Activity of Essential Oils and Individual Components against Acetyl-and Butyrylcholinesterase
Zeitschrift fur Naturforschung - Section C Journal of Biosciences · Ocak 2008
Makale Bilgileri
DergiZeitschrift fur Naturforschung - Section C Journal of Biosciences
Yayın TarihiOcak 2008
Cilt / Sayfa63 · 547-553
Scopus ID2-s2.0-51649097642
Erişim🔓 Açık Erişim
Özet
We have tested acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of nineteen essential oils obtained from cultivated plants, namely one from Anethum graveolens L. (organic fertilizer), two from Foeniculum vulgare Mill. collected at fully-mature and flowering stages (organic fertilizer), two from Melissa officinalis L. (cultivated using organic and chemical fertilizers), two from Mentha piperita L. and M. spicata L. (organic fertilizer), two from Lavandula officinalis Chaix ex Villars (cultivated using organic and chemical fertilizers), two from Ocimum basilicum L. (green and purple-leaf varieties cultivated using only organic fertilizer), four from Origanum onites L., O. vulgare L., O. munitiflorum Hausskn., and O. majorana L. (cultivated using organic fertilizer), two from Salvia sclarea L. (organic and chemical fertilizers), one from S. officinalis L. (organic fertil-izer), and one from Satureja cuneifolia Ten. (organic fertilizer) by a spectrophotometric method of Ellman using ELISA microplate-reader at 1 mg/ml concentration. In addition, a number of single components widely encountered in most of the essential oils [y-terpinene, 4-allyl anisole, (-)-carvone, dihydrocarvone, (-)-phencone, cuminyl alcohol, cumol, 4-isopro-pyl benzaldehyde, trans-anethole, camphene, iso-borneol, (-)-borneol, L-bornyl acetate, 2-decanol, 2-heptanol, methyl-heptanol, farnesol, nerol, iso-pulegol, 1,8-cineole, citral, citronel-lal, citronellol, geraniol, linalool, α-pinene, β-pinene, piperitone, iso-menthone, menthofu-rane, linalyl oxide, linalyl ester, geranyl ester, carvacrol, thymol, menthol, vanilline, and eu-genol] was also screened for the same activity in the same manner. Almost all of the essential oils showed a very high inhibitory activity (over 80%) against both enzymes, whereas the single components were not as active as the essential oils. © 2008, Verlag der Zeitschrift für Naturforschung. All rights reserved.
Yazarlar (4)
1
Ilkay Erdogan Orhan
2
Bilge Şener
3
Murat Kartal
4
Yüksel Kan
Anahtar Kelimeler
Alzheimer's Disease
Anticholinesterase
Essential Oil
Monoterpenes
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Gazi Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
154
Atıf
4
Yazar
4
Anahtar Kelime