Scopus
YÖKSİS Eşleşti
Evaluation of cholinesterase inhibitory and antioxidant activities of wild and cultivated samples of sage (Salvia fruticosa) by activity-guided fractionation
Journal of Medicinal Food · Kasım 2011
YÖKSİS Kayıtları
Evaluation of Cholinesterase Inhibitory and Antioxidant Activities of Wild and Cultivated Samples of Sage (Salvia fruticosa) by Activity-Guided Fractionation
JOURNAL OF MEDICINAL FOOD · 2011 SCI
PROFESÖR YÜKSEL KAN →
Makale Bilgileri
DergiJournal of Medicinal Food
Yayın TarihiKasım 2011
Cilt / Sayfa14 · 1476-1483
Scopus ID2-s2.0-80755182259
Özet
In European folk medicine, Salvia species have traditionally been used to enhance memory. In our previous study of 55 Salvia taxa, we explored significant anticholinesterase activity of cultivated S. fruticosa. In this study, we compared the inhibitory activity of dichloromethane, ethyl acetate, and ethanol extracts of 3 wild-grown samples and 1 cultivated sample of S. fruticosa against acetylcholinesterase and butyrylcholinesterase enzymes (which are associated with pathogenesis of Alzheimer's disease) by using the spectrophotometric Ellman method. Antioxidant activities were assessed by determining 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, iron-chelating capacity, and ferric-reducing antioxidant power. The dichloromethane extract of the cultivated sample was then subjected to fractionation by using open column chromatography and medium-pressure liquid chromatography to obtain the most active fraction by activity-guided fractionation. All fractions and subfractions were tested in the same manner, and inactive subfractions were discarded. The essential oil of the cultivated sample was analyzed by gas chromatography-mass spectrometry. © Copyright 2011, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2011.
Yazarlar (9)
1
F. Sezer Senol
2
Ilkay Erdogan Orhan
3
Sinem Aslan Erdem
4
Murat Kartal
5
Bilge Şener
6
Yüksel Kan
7
Ferhat Celep
ORCID: 0000-0003-3280-8373
8
Ahmet Kahraman
9
Musa Dogan
Anahtar Kelimeler
antioxidant activity
cholinesterase inhibition
chromatography
essential oil
Salvia fruticosa
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Gazi Üniversitesi
Ankara Turkey
Middle East Technical University (METU)
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
34
Atıf
9
Yazar
5
Anahtar Kelime