Scopus
YÖKSİS Eşleşti
Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities
Fitoterapia · Mayıs 2015
YÖKSİS Kayıtları
Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities
FITOTERAPIA · 2015 SCI
PROFESÖR YAVUZ BAĞCI →
Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities
Fitoterapia · 2015 SCI-Expanded
PROFESÖR YAVUZ BAĞCI →
Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities
Fitoterapia · 2015 SCI
PROFESÖR YAVUZ BAĞCI →
Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities
FITOTERAPIA · 2015 SCI
PROFESÖR YÜKSEL KAN →
Makale Bilgileri
DergiFitoterapia
Yayın TarihiMayıs 2015
Cilt / Sayfa103 · 289-293
Scopus ID2-s2.0-84930620915
Özet
Abstract A new prenylated isoflavan, iconisoflavan (1), and a new prenylated isoflav-3-ene, iconisoflaven (2) were isolated from the roots of Glycyrrhiza iconica together with four known ones namely (3S)-licoricidin (3), licorisoflavan A (4), topazolin (5) and glycycoumarin (6). The structures were elucidated on the basis of extensive spectroscopic analysis including 1D and 2D NMR as well as HR-MS. Furthermore, the absolute configurations of compounds 1, 3 and 4 were established by electronic circular dichroism (ECD). All the isolated compounds (1-6) were evaluated for their in vitro antimicrobial activities against five pathogenic bacteria and one yeast (Candida albicans) using an in vitro microdilution method. Compounds 1 and 3-5 displayed significant activity against Salmonella typhimurium ATCC 13311 with MIC values ranging from 2 to 8 μg/mL. Additionally, all compounds were screened for their in vitro free radical scavenging activities using an in vitro microdilution DPPH assay spectrofotometrically. The tested compounds exhibited IC<inf>50</inf> values in the range of 0.18-0.56 mg/mL, suggesting an activity comparable with that of ascorbic acid (IC<inf>50</inf>: 0.07 mg/mL). To the best of our knowledge, the present study constitutes the first phytochemical and bioactivity investigation on G. iconica.
Yazarlar (7)
1
Hasan Kırmızıbekmez
2
Görkem Berk Uysal
3
Milena Masullo
4
Fatih Demirci
5
Yavuz Baʇci
6
Yüksel Kan
7
Sonia Piacente
Anahtar Kelimeler
Antimicrobial and antioxidant activities
Fabaceae
Glycyrrhiza iconica
Isoflavonoids
Kurumlar
Anadolu Üniversitesi
Eskisehir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Salerno
Salerno Italy
Yeditepe University
Istanbul Turkey
Metrikler
28
Atıf
7
Yazar
4
Anahtar Kelime