Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
Chemistry and Biodiversity · Ekim 2021
YÖKSİS Kayıtları
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
CHEMISTRY & BIODIVERSITY · 2021 SCI
Prof. Dr. YÜKSEL KAN →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
Chemistry & Biodiversity · 2021 SCI-Expanded
Prof. Dr. YÜKSEL KAN →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
Chemistry & Biodiversity · 2021 SCI-Expanded
Dr. Öğr. Üyesi İREM AYRAN ÇOLAK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
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2019 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi İREM AYRAN ÇOLAK →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI-Expanded Q3
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Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
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Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential ofHaplophyllum sahiniiandH. vulcanicumExtracts
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Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
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Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI Q3
Prof. Dr. YÜKSEL KAN →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. MEHMET TUZCU →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
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Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies
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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Screening for Antioxidant Effects and Chemical Profiles of Different Extracts of Rheum ribes Parts
2025 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. ATİLLA ARSLAN →
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Prof. Dr. EMİNE ARSLAN →
Makale Bilgileri
ISSN16121872
Yayın TarihiEkim 2021
Cilt / Sayfa18
Scopus ID2-s2.0-85113290749
Özet
The antioxidant and mutagenic/antimutagenic activities of the fixed oils from Nigella sativa (NSO) and Nigella damascena (NDO) seeds, obtained by cold press-extraction from the cultivar samples, were comparatively investigated for the first time. The antimutagenicity test was carried out using classical and modified Ames tests. The fatty acid composition of the fixed oils was characterized by gas chromatography–mass spectrometry (GC-MS) while the quantification of thymoquinone in the fixed oils was determined by UPC2. The main components of the NSO and NDO were found to be linoleic acid, oleic acid, and palmitic acid. The results of the Ames test confirmed the safety of NSO and NDO from the viewpoint of mutagenicity. The results of the three antioxidant test methods were correlated with each other, indicating NDO as having a superior antioxidant activity, when compared to the NSO. Both NSO and NDO exhibited a significant protective effect against the mutagenicity induced by aflatoxin B1 in Salmonella typhimurium TA98 and TA100 strains. When microsomal metabolism was terminated after metabolic activation of the mycotoxin, a significant increase in antimutagenic activity was observed, suggesting that the degradation of aflatoxin B1 epoxides by these oils may be a possible antimutagenic mechanism. It is worthy to note that this is the first study to assess the mutagenicity of NSO and NDO according to the OECD 471 guideline and to investigate antimutagenicity of NDO in comparison to NSO against aflatoxin.
Yazarlar (9)
1
Sinem Helvacıoğlu
2
Mohammad Charehsaz
3
Etil Guzelmeric
ORCID: 0000-0001-9696-3271
4
Mehmet Ali Oçkun
ORCID: 0000-0001-8180-7399
5
İrem Ayran
6
Hasan Kırmızıbekmez
7
Yüksel Kan
8
Ahmet Aydın
9
Erdem Yesilada
Anahtar Kelimeler
antimutagenic activity
antioxidants
mutagenesis
Nigella damascene
Nigella sativa
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Yeditepe University
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Chemistry and Biodiversity
Q3
SJR Skoru0,425
H-Index87
YayıncıWiley-Blackwell
ÜlkeUnited States
Biochemistry (Q3)
Bioengineering (Q3)
Chemistry (miscellaneous) (Q3)
Medicine (miscellaneous) (Q3)
Molecular Biology (Q4)
Molecular Medicine (Q4)
Metrikler
12
Atıf
9
Yazar
5
Anahtar Kelime