Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
Chemistry and Biodiversity · Ocak 2023
YÖKSİS Kayıtları
Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
CHEMISTRY & BIODIVERSITY · 2022 SCI-Expanded
Prof. Dr. YÜKSEL KAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential of iHaplophyllum sahinii/i and iH. vulcanicum/i Extracts/title
2019 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. OSMAN TUGAY →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi İREM AYRAN ÇOLAK →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. YÜKSEL KAN →
A ProspectiveofMultipleBiopharmaceuticalActivitiesofProcyanidins-RichUapacatogoensisPaxExtracts:HPLC-ESI-TOF-MSCoupledwithBioinformaticsAnalysis
2021 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. ABDURRAHMAN AKTÜMSEK →
A comparative study of chemical profiling and biological effects of Doronicum orientale extracts
2022 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. EVREN YILDIZTUGAY →
Synthesis and Characterization of Copper\u2010Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. NURANİYE ERUYGUR →
Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi CEYLAN DÖNMEZ →
Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential ofHaplophyllum sahiniiandH. vulcanicumExtracts
2019 ISSN: 1612-1872 SSCI
Arş. Gör. ESENGÜL ÖZKAYMAKOĞLU →
Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
2022 ISSN: 1612-1872 SCI-Expanded Q3
Doç. Dr. FATMA AYAZ →
Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
2022 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. YÜKSEL KAN →
Protective Effect of Nigella sativa and Nigella damascena Fixed Oils Against Aflatoxin Induced Mutagenicity in the Classical and Modified Ames Test
2021 ISSN: 1612-1872 SCI Q3
Prof. Dr. YÜKSEL KAN →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. MEHMET TUZCU →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Arş. Gör. TUĞSEN BÜYÜKYILDIRIM →
Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells
2023 ISSN: 1612-1872 SCI
Prof. Dr. YÜKSEL KAN →
Antioxidant and Enzyme Inhibitory Activities of Rhoifolin Flavonoid: In Vitro and in Silico Studies
2023 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. GÖKHAN ZENGİN →
Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
Doç. Dr. FATMA AYAZ →
Enzyme Inhibitory and Antioxidant Potential with Phytochemical Analysis of Satureja hasturkii H.Duman & Dirmenci: A New Record From Türkiye
2025 ISSN: 1612-1872 SCI-Expanded
Arş. Gör. TUĞSEN BÜYÜKYILDIRIM →
Screening for Antioxidant Effects and Chemical Profiles of Different Extracts of Rheum ribes Parts
2025 ISSN: 1612-1872 SCI-Expanded
Prof. Dr. ATİLLA ARSLAN →
Screening for Antioxidant Effects and Chemical Profiles of Different Extracts of Rheum ribes Parts
2025 ISSN: 1612-1872 SCI-Expanded Q3
Prof. Dr. EMİNE ARSLAN →
Makale Bilgileri
ISSN16121872
Yayın TarihiOcak 2023
Cilt / Sayfa20
Scopus ID2-s2.0-85143773848
Özet
Cytotoxic activity-guided fractionation studies on Glycyrrhiza echinata roots led to the isolation of eight compounds (1–8). Chemical structures of the isolates were identified by NMR and MS analysis. Among the tested molecules, retrochalcones namely echinatin (3) (IC50=23.45–41.83 μM), licochalcone B (4) (IC50=36.04–39.53 μM) and tetrahydroxylmethoxychalcone (5) (IC50=7.09–80.81 μM) were the most active ones against PC3, MCF7 and HepG2 cells. Moreover, 5 exhibited selectivity on prostate cancer cells (SI: 5.19). Hoechst staining and Annexin V/PI binding assays as well as cell cycle analysis on the compounds 3 (23 μM) and 5 (5 and 7 μM) demonstrated that these retrochalcones induced apoptosis and significantly suppressed cell cycle in G1 and G2/M phases. Furthermore, 3 and 5 showed antimigratory effects on PC3 cells by wound healing assay. The results indicated that tested retrochalcones most particularly 5 could be potential anticancer drug candidates that prevent proliferation and migration of cancer cells.
Yazarlar (5)
1
Dicle Çevik
ORCID: 0000-0001-9257-5765
2
Suat Erdogan
3
Riza Serttas
4
Yüksel Kan
5
Hasan Kırmızıbekmez
Anahtar Kelimeler
apoptosis
bioassay-guided isolation
cytotoxic activity
Glycyrrhiza echinata
retrochalcone
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Trakya Üniversitesi
Edirne Turkey
Trakya University, Faculty of Medicine
Edirne Turkey
Yeditepe University
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Chemistry and Biodiversity
Q3
SJR Skoru0,425
H-Index87
YayıncıWiley-Blackwell
ÜlkeUnited States
Biochemistry (Q3)
Bioengineering (Q3)
Chemistry (miscellaneous) (Q3)
Medicine (miscellaneous) (Q3)
Molecular Biology (Q4)
Molecular Medicine (Q4)
Metrikler
11
Atıf
5
Yazar
5
Anahtar Kelime