Scopus
🔓 Açık Erişim
Comprehensive Analysis of the Chemical and Bioactivity Profiles of Endemic Crataegus turcicus Dönmez in Comparison with Other Crataegus Species
Molecules · Eylül 2023
Makale Bilgileri
DergiMolecules
Yayın TarihiEylül 2023
Cilt / Sayfa28
Scopus ID2-s2.0-85172806180
Erişim🔓 Açık Erişim
Özet
Crataegus turcicus is a plant endemic to Türkiye. For the first time, this study aimed to comparatively assess its flower-bearing branches, leaves, and fruits with other well-known Crataegus species (C. monogyna, C. pentagyna, and C. orientalis) in terms of chemical composition and bioactivity studies to evaluate its potential use as a food supplement. Firstly, the contents of total phenolics (TPC), flavonoids (TFC), proanthocyanidin (TPAC), and anthocyanin (TAC) in different plant parts of Crataegus species were evaluated. The highest TPAC was found in the hydroalcoholic extract of C. turcicus flower-bearing branches. Moreover, all plant parts had comparatively higher amounts of TPC, TFC, and TAC compared to other Crataegus species. The chemical screening by high-performance thin-layer chromatography (HPTLC) resulted that C. turcicus parts were rich with chlorogenic acid, neochlorogenic acid, quercetin and vitexin derivatives, epicatechin, procyanidin, etc., and their quantities were evaluated by high-performance liquid chromatography (HPLC). In terms of several in vitro antioxidant activity outcomes, the flower-bearing branches of C. turcicus showed the highest antioxidant activity by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) test among the assessed antioxidant assays. Additionally, hydroalcoholic extracts of C. turcicus significantly decreased LPS-induced nitric oxide, tumor necrosis factor-alpha, and interleukin-6 production more potently than indomethacin (positive control). In addition to its remarkable anti-inflammatory activity, C. turcicus showed analgesic activity by reducing prostaglandin E2 levels.
Yazarlar (8)
1
Tansu Turnalar Ülger
ORCID: 0009-0000-6459-0060
2
Mehmet Ali Oçkun
ORCID: 0000-0001-8180-7399
3
Etil Guzelmeric
ORCID: 0000-0001-9696-3271
4
Nisa Beril Sen
ORCID: 0000-0001-8422-8835
5
Hande Sipahi
ORCID: 0000-0001-6482-3143
6
Yağmur Özhan
ORCID: 0000-0001-6173-3281
7
Yüksel Kan
8
Erdem Yesilada
Anahtar Kelimeler
analgesic activity
anti-inflammatory activity
antioxidant activity
CrataegusL
Crataegus turcicus
phenolic profiling
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Yeditepe University
Istanbul Turkey
Metrikler
16
Atıf
8
Yazar
6
Anahtar Kelime