Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
Revista Cientifica De La Facultad De Veterinaria · Ocak 2023
YÖKSİS Kayıtları
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
Revista Científica · 2023 Google scholar, sci, EBSCO, SCİ ELO, DOAJ, Latindex
Prof. Dr. ÖZGÜR ÖZDEMİR →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
Universidad del Zulia · 2023 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
Revista Científica · 2023 Google scholar, sci, EBSCO, SCİ ELO, DOAJ, Latindex
Prof. Dr. AHMET LEVENT BAŞ →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
Revista Cientifica de la Facultad de Ciencias Veterinarias de la Universidad del Zulia · 2023 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ÖZGÜR ÖZDEMİR →
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. MEHMET TUZCU →
Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded Q4
Arş. Gör. ZEYNEP ÇELİK KENAR →
Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
Determination of Embryotoxic effects of Atipamezole using in ovo model
2023 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN KIZILAY →
Evaluation of tumor necrosis Factor Alpha, Interferon Gamma, Procalcitonin and Neopterin levels in Brucella seropositive cattle
2023 ISSN: 0798-2259 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ÖZLEM DERİNBAY EKİCİ →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 Google scholar, sci, EBSCO, SCİ ELO, DOAJ, Latindex
Prof. Dr. AHMET LEVENT BAŞ →
Determination of the embryotoxic effect of Metronidazole using an in ovo model
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN KIZILAY →
ELISA–based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 CABI
Prof. Dr. OĞUZHAN AVCI →
ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. NERMİN IŞIK USLU →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. AHMET LEVENT BAŞ →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ZAFER SAYIN →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
Doç. Dr. ASLI BALEVİ →
Morphometric investigation of the effects of Azoxymethane, Diallyl disulfide and corn oil use on humerus and femur development in rats
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
Doç. Dr. ALİ USLU →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ENDER ERDOĞAN →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Pathological and biochemical investigation of the effects of Silybum marianum against Methomyl damage in broiler liver
2024 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of propolis on pyruvate kinase and superoxide dismutase activities in doxorubicin–induced tissue damage: Molecular docking analysis
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN YONAR →
Makale Bilgileri
ISSN07982259
Yayın TarihiOcak 2023
Cilt / Sayfa33
Scopus ID2-s2.0-85172909590
Erişim🔓 Açık Erişim
Özet
Colon cancer (CRC) is one of the most common types of cancer in the world. In this study, the effects of Tarantula cubensis alcoholic extract (TCAE) and the Capecitabine in CRC were investigated. Wistar albino rats were divided into eight groups with 12 animals in each group: untreated healthy and CRC groups, healthy and CRC groups treated with TCAE or Capecitabine, and healthy and CRC groups treated with both TCAE and Capecitabine. Azoxymethane was used in all CRC groups. TCAE and Capecitabine were administered to the relevant groups starting in the 15th week. All rats were euthanized after 18 weeks, and tissue samples were collected. The mRNA levels of Bcl–2, Bax, and Cas–3 in the harvested tissues were determined using real–time PCR and histopathologically abnormal crypt foci (ACF) scores were determined. It was found that TCAE modulated the decreased Bax/Bcl–2 expression rate in the CC group, but had the opposite effect in healthy animals, which was significantly reduced compared to the healthy groups (P<0.05). In addition, this rate was significantly lower in Capecitabine administered groups compared to other groups, and a paradoxical effect was observed (P<0.05). No significant change was observed in Cas–3 expression levels in all groups (P>0.05). Importantly, single and combined use of TCAE and Capecitabine in rats with CRC significantly reduced ACF scores (P<0.05). It can be stated that TCAE can specifically modulate the decreased Bax/Bcl–2 ratio in animals with cancer, and the therapeutic efficacy of Capecitabine is achieved at a dose of 40 mg·kg-1.
Yazarlar (3)
1
Rahmi Canbar
ORCID: 0000-0001-7100-4437
2
O. Ozdemir
3
A. L. Baş
Anahtar Kelimeler
Azoxymethane
Capecitabine
colorectal cancer
TCAE
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Revista Cientifica de la Facultad de Veterinaria
Q4
OA
SJR Skoru0,138
H-Index16
YayıncıUniversidad del Zulia, Facultad de Ciencias Veterinarias
ÜlkeVenezuela
Animal Science and Zoology (Q4)
Food Science (Q4)
Immunology and Microbiology (miscellaneous) (Q4)
Veterinary (miscellaneous) (Q4)
Metrikler
3
Atıf
3
Yazar
4
Anahtar Kelime