Scopus
Effect of Iron Supplementation on Oxidative Stress and Antioxidant Status in Iron-Deficiency Anemia
Biological Trace Element Research · Aralık 2003
Makale Bilgileri
DergiBiological Trace Element Research
Yayın TarihiAralık 2003
Cilt / Sayfa96 · 117-123
Scopus ID2-s2.0-1642561883
Özet
This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glutathione peroxidase (GSH-Px), and the activities of superoxide dismutase (SOD) and catalase in 63 patients with iron-deficiency anemia before and after 6 wk of iron supplementation and at the time when body iron stores are saturated. After 6 wk of iron supplementation, a significant decrease of oxidative stress was observed in the treated subjects relative to controls (p<0.05). No significant differences existed between treated patients at 6 wk and at the end of the study. The erythrocyte levels of catalase, SOD, and GSH-Px were significantly lower in treated patients relative to controls (p<0.05). These levels increased after 6 wk of supplementation (p<0.05) and showed no significant differences with those at the end of the study.
Yazarlar (4)
1
Erdal Kurtoglu
2
Aysegul Ugur
3
Abdulkerim Kasim Baltaci
4
Levent Undar
Anahtar Kelimeler
Antioxidants
Iron-deficiency anemia
Iron replacement
Oxidative stress
Kurumlar
Akdeniz Üniversitesi
Antalya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
104
Atıf
4
Yazar
4
Anahtar Kelime