CANLI
Yükleniyor Veriler getiriliyor…
/ Makaleler / Scopus Detay
Scopus YÖKSİS DOI Eşleşti SJR Q1

The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes

Theriogenology · Aralık 2021

YÖKSİS DOI Eşleşmesi Bulundu

Bu Scopus makalesi YÖKSİS veritabanında da kayıtlı. Aşağıda YÖKSİS verilerini görebilirsiniz.

YÖKSİS Kayıtları
The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes
Theriogenology · 2021 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes
Theriogenology · 2021 SCI-Expanded
Doç. Dr. HASAN ALKAN →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Protective effect of esterified glucomannan on aflatoxin inducedchanges in testicular function sperm quality and seminal plasmabiochemistry in rams
2014 ISSN: 0093-691X SSCI
Prof. Dr. EMRAH SUR →
Protective effect of esterified glucomannan on aflatoxin induced changes in testicular function sperm quality and seminal plasma biochemistry in rams
2014 ISSN: 0093691X SCI-Expanded
Prof. Dr. NURCAN DÖNMEZ →
The influence of trehalose taurine cysteamine and hyaluronan on ram semen
2007 ISSN: 0093691X SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effect of glutamine and sugars after bull spermatozoa cryopreservation
2011 ISSN: 0093691X SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Detection of Brucella canis from inguinal lymph nodes of naturally infected dogs by PCR
2010 ISSN: 0093691X SSCI
Prof. Dr. UÇKUN SAİT UÇAN →
Protective effect of esterified glucomannan on aflatoxin induced changes in testicular function sperm quality and seminal plasma biochemistry in rams
2014 ISSN: 0093691X SSCI
Prof. Dr. HASAN HÜSEYİN DÖNMEZ →
DNA Damaging Effect of Paclitaxel in the Epididymal Sperms as a Chemotherapeutic Agent and Possible Remedies to Prevent this Effect: A Study on Reproductive Potential of Male Cancer Patients of Reproductive Age
2019 ISSN: 0093-691X SCI Q1
Prof. Dr. MUSTAFA NUMAN BUCAK →
Protective effect of esterified glucomannan on aflatoxin-induced changes in testicular function, sperm quality, and seminal plasma biochemistry in rams
2014 ISSN: 0093-691X SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
The effect of anti-müllerian hormone and progesterone concentrations on superovulation response and embryo yield in goats
2020 ISSN: 0093-691X SCI
Doç. Dr. KÜBRA KARAKAŞ ALKAN →
Chronological echocardiographic evaluation of left ventricular systolic and diastolic function in term and premature neonatal calves
2020 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. MERVE İDER →
Chronological echocardiographic evaluation of left ventricular systolic and diastolic function in term and premature neonatal calves
2020 ISSN: 0093-691X SCI-Expanded
Doç. Dr. AMİR NASERİ →
The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes
2021 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. HASAN ALKAN →
The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes
2021 ISSN: 0093-691X SCI-Expanded Q1
Prof. Dr. KAMİL ÜNEY →
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
2022 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. MERVE İDER →
The pharmacokinetics of letrozole and its effect on gonadotropins in anestrous ewes
2021 ISSN: 0093-691X SCI-Expanded
Prof. Dr. İBRAHİM AYDIN →
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
2022 ISSN: 0093-691X SCI Q1
Prof. Dr. KAMİL ÜNEY →
Serum sRAGE and sE-selectin levels are useful biomarkers of lung injury and prediction of mortality in calves with perinatal asphyxia
2022 ISSN: 0093-691X SCI-Expanded
Prof. Dr. MAHMUT OK →
The effects of glutathione supplementation on post-thawed Turkey semen quality and oxidative stress parameters and fertilization, and hatching potential
2022 ISSN: 0093-691X SCI-Expanded
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effect of strategies to increase progesterone levels on fertility of bovine embryo transfer recipients - A meta-analysis
2024 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. HASAN ALKAN →
Effect of strategies to increase progesterone levels on fertility of bovine embryo transfer recipients - A meta-analysis
2024 ISSN: 0093-691X SCI-Expanded Q1
Doç. Dr. FATMA SATILMIŞ →

Makale Bilgileri

Dergi Theriogenology
ISSN0093691X
Yayın TarihiAralık 2021
Cilt / Sayfa176 · 225-232
DOI10.1016/j.theriogenology.2021.09.033
Scopus ID2-s2.0-85116590794
Özet The aim of this study was to determine the pharmacokinetics of letrozole and its effect on FSH and LH concentrations after single (IV, IM, SC) and repeated IV doses in anestrous ewes. This study was conducted in experiments 1 and 2 by randomly dividing 24 healthy Akkaraman ewes in anestrus into two equal groups. In experiment 1, the pharmacokinetics of letrozole following single IV, IM, and SC administration at 1 mg/kg dose and its effect of a single IV dose on plasma FSH and LH concentration were determined. In experiment 2, the effect of repeated IV doses of letrozole on FSH and LH concentrations was established. Plasma concentration of letrozole was measured using high-performance liquid chromatography, and pharmacokinetic parameters were calculated by non-compartmental analysis. FSH and LH concentrations were quantified using ELISA. The elimination half-life (t1/2ʎz) for IV, IM, and SC routes were 9.94, 37.29, and 41.07 h, respectively. The IV route for letrozole had a total clearance of 0.11 L/h/kg and a volume of distribution at a steady state of 1.50 L/kg. The peak plasma concentration was 0.11 μg/mL for the IM route and 0.14 μg/mL for the SC routes. The bioavailability was 55.18% for the IM route and 75.34% for the SC route. Letrozole following single and repeated (every 24 h for 3 days) IV administrations at 1 mg/kg dose did not affect LH concentration in anestrous ewes but caused an increase in the FSH concentration. This increase in FSH concentration may create a potential for the use of letrozole in ovarian superstimulation protocols. Favorable pharmacokinetic properties (long t1/2ʎz and good bioavailability) of letrozole for IM and SC routes require further investigation before use in estrus induction or estrus synchronization protocols in sheep.

Yazarlar (6)

1
M. B. Kivrak
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
Hasan Alkan
ORCID: 0000-0001-8332-5334
4
O. Atik
5
Ibrahim Aydin
6
Kamil Üney
ORCID: 0000-0002-8674-4873

Anahtar Kelimeler

Anestrous ewes FSH Letrozole LH Pharmacokinetics

Kurumlar

Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Theriogenology
Q1
SJR Skoru0,780
H-Index160
YayıncıElsevier Inc.
ÜlkeUnited States
Animal Science and Zoology (Q1)
Equine (Q1)
Food Animals (Q1)
Small Animals (Q1)
Dergi sayfasına git

Metrikler

7
Atıf
6
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

HA
HASAN ALKAN
Doç. Dr.

Hızlı Erişim

DOI ile aç Scopus'ta aç Makaleler listesi