Scopus
🔓 Açık Erişim
Long term used testosterone may cause heart and liver damage
Journal of Animal and Veterinary Advances · Ekim 2010
Makale Bilgileri
DergiJournal of Animal and Veterinary Advances
Yayın TarihiEkim 2010
Cilt / Sayfa9 · 2343-2345
Scopus ID2-s2.0-77958468482
Erişim🔓 Açık Erişim
Özet
The purpose of the research is to define the effects of testosterone on heart, liver, kidney and some chemical values in male rats during puberty. In the research 16 Sprague dawley rats, 50 days old were used. The rats were divided into two equal groups. The first group was administrated testosterone, diluted with olive oil, 5 mg kg-1 (SID) subcutaneously for 10 weeks 5 days each week. The second group was only given olive oil. At the end of the 1 Oth week blood samples were taken. Serum creatme kinase, creatme kinase-MB, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, triglyceride, cholesterol, high density lipoprotein, amylase, total protein, albumin and calcium were measured with an auto-analyzer. It was determined that while testosterone application in male rats led to increase on the serum CK-MB, CK and AST levels (p<0.05), it caused decreases on the total protein, albumin, calcium and creatinine (p<0.05). As a result, it can be stated that long term testosterone implication during puberty may lead to heart and liver defects at early ages. © Medwell Journals, 2010.
Yazarlar (4)
1
Sefa Lök
2
Erdal Tasgin
3
Nagehan Demir
4
Mehmet Ozdemir
Anahtar Kelimeler
Albumen
Aspartate aminotransferase
Creatine kinase-MB
Creatme kinase
Serum
Testosterone
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
8
Atıf
4
Yazar
6
Anahtar Kelime