Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise
Bratislava Medical Journal · Aralık 2012
YÖKSİS Kayıtları
Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise
Bratislava Medical Journal · 2012 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise
Bratislava Medical Journal · 2012 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiAralık 2012
Cilt / Sayfa113 · 698-701
Scopus ID2-s2.0-84871762947
Erişim🔓 Açık Erişim
Özet
Background: The present study aimed to explore the effect of melatonin administration on lipid peroxidation in various tissues of rats with streptozocin induced diabetes and subjected to an acute swimming exercise. Methods: The study used 80 adult male rats, which were equally allocated to 8 groups: Group 1, general control; Group 2, melatonin-administered control; Group 3, melatonin-administered diabetic control; Group 4, swimming control; Group 5, melatonin-administered swimming; Group 6, melatonin-administered diabetic swimming; Group 7, diabetic swimming; Group 8, diabetic control. Diabetic rats were administered 3 mg/kg/day ip melatonin for 4 weeks. At the end of the study, the animals were decapitated to collect samples from liver, lung and spleen tissues, which were then analyzed to determine levels of liver MDA (nmol/gram/protein) and GSH (mg/g/protein). Results: The highest MDA values in liver, lung and spleen tissues were obtained in the Group 7. The values in the Group 8 were lower than those in the Group 7, but higher than in all other groups. The Group 5 and 6 had the highest liver, lung and spleen GSH values. Conclusion: Results obtained from the study indicate that the increase in free radical production and the inhibition of antioxidant activity in diabetes and acute exercise are both prevented by melatonin administration.
Yazarlar (7)
1
Mursel Bicer
2
M. Akil
3
Abdulkerim Kasim Baltaci
4
Rasim Mogulkoc
5
Abdullah Sivrikaya
6
Mehmet Gunay
ORCID: 0000-0003-0047-2203
7
Hasan Akkuş
Anahtar Kelimeler
Diabetes
Exercise
Lipid peroxidation
Melatonin
Rat
Kurumlar
Gazi Üniversitesi
Ankara Turkey
Karabük Üniversitesi
Karabuk Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
8
Atıf
7
Yazar
5
Anahtar Kelime