Scopus
YÖKSİS Eşleşti
The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats
Hormone Molecular Biology and Clinical Investigation · Aralık 2017
YÖKSİS Kayıtları
The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats
Hormone Molecular Biology and Clinical Investigation · 2017 ESCI
PROFESÖR ABDULKERİM KASIM BALTACI →
The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats
Hormone Molecular Biology and Clinical Investigation · 2017 ESCI
PROFESÖR ABDULKERİM KASIM BALTACI →
The effect of thyroid dysfunction on nesfatin-1 and adiponectin levels in rats
Hormone Molecular Biology and Clinical Investigation · 2017 SCI-Expanded
PROFESÖR ESMA MENEVŞE →
Makale Bilgileri
DergiHormone Molecular Biology and Clinical Investigation
Yayın TarihiAralık 2017
Cilt / Sayfa32
Scopus ID2-s2.0-85037699706
Özet
Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1.5 mg/kg/day) for 1 week]; (4) hyperthyroidism [hyperthyroidism was induced by 3-weeks' thyroxine injection (0.3 mg/kg/day)]; (5) hyperthyroidism + PTU (after hyperthyroidism was induced by 2-weeks' thyroxine injection, the animals were given 10 mg/kg/day PTU for 1 week). Blood samples taken at the end of the study were analyzed to measure nesfatin-1 and adiponectin levels. It was found that nesfatin-1 levels increased in hypothyroidism, while adiponectin levels decreased (p < 0.001). In experimental hyperthyroidism, on the other hand, both nesfatin-1 and adiponectin levels were found significantly elevated (p < 0.001). The results of the study indicate that nesfatin-1 and adiponectin levels were modified considerably in hypo- and hyperthyroidism, whereas with the restoration of the thyroid function, modified hormone levels went back to normal.
Yazarlar (4)
1
Emine Atici
2
Rasim Mogulkoc
3
Abdulkerim Kasim Baltaci
4
Esma Menevşe
Anahtar Kelimeler
adiponectin
nesfatin-1
rat
thyroid dysfunction
Kurumlar
Başkent Üniversitesi
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
5
Atıf
4
Yazar
4
Anahtar Kelime