Scopus
YÖKSİS Eşleşti
The effects of zinc and melatonin on muscle ischaemi-reperfusion injury in rat
Cellular and Molecular Biology · Ocak 2018
YÖKSİS Kayıtları
The effects of zinc and melatonin on muscle ischaemi-reperfusion injury in rat
CELLULAR AND MOLECULAR BIOLOGY · 2018 SCI-Expanded
PROFESÖR RASİM MOĞULKOÇ →
The effects of zinc and melatonin on muscle ischaemi-reperfusion injury in rat
CELLULAR AND MOLECULAR BIOLOGY · 2018 SCI-Expanded
PROFESÖR ABDULKERİM KASIM BALTACI →
Makale Bilgileri
DergiCellular and Molecular Biology
Yayın TarihiOcak 2018
Cilt / Sayfa6 · 1-4
Scopus ID2-s2.0-85042782968
Özet
Ischemia-reperfusion leads to damage in cell or tissue due to insufficient blood flow. The aim of present study was to determine the effect of zinc, melatonin and zinc + melatonin supplementations during 3 weeks on muscle tissue and plasma MDA and GSH levels. This study was performed on 38 male Wistar- Albino rats. Experiments groups were designed as sham-control, ischemia-reperfusion (I/R), zinc + I/R, melatonin + I/R and zinc + melatonin + I/R Ischemia-reperfusion was induced by left femoral artery occlusion (1 hour) and reopening (1 hour). At the end of experiments tissue and blood samples were analysed for MDA and GSH. MDA levels were increased, GSH levels decreased in I/R groups. However, zinc and melatonin supplementation inhibited MDA and increased GSH levels in I/R groups. The results of present study show that increased lipid peroxidation in muscle tissue by ischemia-reperfusion may be prevented by zinc and melatonin or zinc plus melatonin supplementation.
Yazarlar (4)
1
Mehmet Celer
2
Rasim Mogulkoc
3
Abdulkerim Kasim Baltaci
4
Dervis Dasdelen
Anahtar Kelimeler
Free radical
Ischemia-reperfusion
Melatonin
Muscle
Zinc
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
6
Atıf
4
Yazar
5
Anahtar Kelime