Scopus
YÖKSİS Eşleşti
Effect of pinealectomy and melatonin supplementation on metallothionein, ZnT2, ZIP2, ZIP4 and zinc levels in rat small intestine
Biotechnic and Histochemistry · Ocak 2021
YÖKSİS Kayıtları
Effect of pinealectomy and melatonin supplementation on metallothionein,
ZnT2, ZIP2, ZIP4 and zinc levels in rat small intestine
BIOTECHNIC & HISTOCHEMISTRY · 2021 SCI-Expanded
PROFESÖR RASİM MOĞULKOÇ →
The Effect of Pinealectomy and Melatonin Supplementation on Metallothionein, ZnT2, ZIP2, ZIP4 and Zinc Levels in Different Parts of the Rat Small Intestines
Biotechnic and Histochemistry · 2021 SCI-Expanded
PROFESÖR ABDULKERİM KASIM BALTACI →
Makale Bilgileri
DergiBiotechnic and Histochemistry
Yayın TarihiOcak 2021
Cilt / Sayfa96 · 623-635
Scopus ID2-s2.0-85101285253
Özet
We investigated the relations among levels of metallothionein (MT); zinc (Zn) transport proteins, ZnT2, ZIP2 (ZRT and IRT-like proteins); and ZIP4, which enable Zn absorption in the small intestine of rats. We also investigated tissue Zn levels in the small intestine. We used four groups of adult male rats: group 1, control; group 2, pinealectomy (Px); group 3, Px + melatonin (MEL); group 4, MEL only. Animals in groups 3 and 4 were administered 5 mg/kg/day MEL for four weeks. At the end of the study, all animals were sacrificed and samples of duodenum, jejunum and ileum were harvested to analyze ZnT2, ZIP2, ZIP4 and MT levels using immunohistochemistry, and tissue Zn levels were measured by atomic absorption spectrophotometry. The lowest ZnT2 levels in the duodenum, jejunum and ileum, and the lowest ZIP2 levels in the duodenum and ileum were found in group 2. The lowest ZIP4 levels were found in the duodenum and jejunum, and the lowest MT levels in the duodenum and ileum were found in group 2. The highest MT values in the ileum were found in group 4. We found that ZnT2, ZIP2, ZIP4 and MT levels were reduced in the ileum compared to controls following Px, but levels approached control values after MEL administration. By its effects on ZnT2, ZIP2, ZIP4 and MT levels, MEL participates in the absorption of Zn in the rat small intestine.
Yazarlar (4)
1
Omer Unal
2
Abdulkerim Kasim Baltaci
3
Rasim Mogulkoc
4
Mustafa Avunduk
Anahtar Kelimeler
Melatonin
metallothionein
pinealectomy
rat
small intestine
zinc transporter proteins
ZIP2
ZIP4
ZnT2
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
4
Yazar
9
Anahtar Kelime