Scopus
YÖKSİS Eşleşti
The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats
Biological Trace Element Research · Mart 2021
YÖKSİS Kayıtları
The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels, and Element Metabolism in DMBA-Induced Breast Cancer in Rats
Biological Trace Element Research · 2021 SCI-Expanded
PROFESÖR RASİM MOĞULKOÇ →
The Effect of Zinc and Melatonin Administration on Lipid Peroxidation, IL-6 Levels and Element Metabolism in DMBA-Induced Breast Cancer in Rats.
Biological Trace Element Research · 2021 SCI-Expanded
PROFESÖR ABDULKERİM KASIM BALTACI →
Makale Bilgileri
DergiBiological Trace Element Research
Yayın TarihiMart 2021
Cilt / Sayfa199 · 1044-1051
Scopus ID2-s2.0-85086776209
Özet
The purpose of this study was to investigate the effects of zinc and melatonin administration on interleukin-6, lipid peroxidation parameters, and element metabolism in DMBA-induced breast cancer in female rats. A total of 42 recently weaned Wistar rats were divided into 5 groups as follows: control (group 1), DMBA control (group 2), DMBA + zinc (group 3), DMBA + melatonin (group 4), and DMBA + melatonin and zinc (group 5). Malondialdehyde (MDA) and glutathione (GSH) levels in breast tissue and blood samples were determined via spectrophotometric methods. In addition, iron, magnesium, zinc, and copper levels in serum samples were determined by atomic emission, and plasma interleukin-6 levels were determined by ELISA method. The highest tissue and plasma MDA and the lowest tissue and erythrocyte GSH levels found in the study were in group 2; the highest tissue and erythrocyte GSH levels and the lowest tissue and plasma MDA levels are in group 5 (P < 0.05). Iron, magnesium, and zinc levels of groups 3, 4, and 5 were higher than the DMBA group without administration (group 2), but the copper values were significantly lower (P < 0.05). The highest IL-6 levels were determined in group 2 while IL-6 levels in the DMBA group (G5) treated with combined melatonin and zinc were lower than all other breast cancer groups (P < 0.05). According to the findings obtained in this presented study, combined zinc and melatonin therapy can contribute to the prevention of tumor growth by improving the disruption in element metabolism and suppressing IL-6 levels and reducing tissue damage that causes the cancer.
Yazarlar (5)
1
Elif Gulbahce-Mutlu
2
Saltuk Bugra Baltaci
3
Esma Menevşe
4
Rasim Mogulkoc
5
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
Breast cancer
DMBA
IL-6
Lipid peroxidation
Rat
Trace element
Kurumlar
Karatay Üniversitesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
19
Atıf
5
Yazar
6
Anahtar Kelime