Scopus
YÖKSİS Eşleşti
The effects of thyroid dysfunction on DNA damage and apoptosis in liver and heart tissues of rats
Hormone Molecular Biology and Clinical Investigation · Mart 2022
YÖKSİS Kayıtları
The effects of thyroid dysfunction on DNA damage and apoptosis in liver and heart tissues of rats
Horm Mol Biol Clin Investig · 2022 EBSCO
PROFESÖR RASİM MOĞULKOÇ →
The effects of thyroid dysfunction on DNA damage and apoptosis in liver and heart tissues of rats
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION · 2022 Chemical Abstracts Services (CAS)
PROFESÖR ABDULKERİM KASIM BALTACI →
The effects of thyroid dysfunction on DNA damage and apoptosis in liver and heart tissues of rats
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION · 2022 Chemical Abstracts Services (CAS)
PROFESÖR ABDULLAH SİVRİKAYA →
Makale Bilgileri
DergiHormone Molecular Biology and Clinical Investigation
Yayın TarihiMart 2022
Cilt / Sayfa43 · 47-53
Scopus ID2-s2.0-85118215099
Özet
Objectives: Thyroid hormones affect many enzymes, organs, and systems. They also play a role in complex biological events including development and growth. The main objective of this study was to analyze the effects of thyroid dysfunction on DNA damage and apoptosis in liver and heart tissues as well as the treatment of these disorders. Methods: Thirty-eight Wistar-albino male rats were randomly divided into five groups: 1. Control group (n=6): The rats were sacrificed without any application and liver and heart samples were collected. 2. Hypothyroidism group (n=8): Prophyltiouracil (PTU)-10 mg/kg/day was applied to induce hypothyroidism by intraperitoneal route for two weeks. 3. Hypothyroidism + Thyroxine group (n=8): After one week of PTU application (10 mg/kg/day), a high dose of l-thyroxine (1.5 mg/kg/day) was applied by intraperitoneal route for one week. 4. Hyperthyroidism group (n=8): l-thyroxine (0.3 mg/kg/day) was applied intraperitoneally to induce hyperthyroidism for two weeks. 5. Hyperthyroidism + PTU group (n=8): After one week of high dose l-thyroxine application, PTU (10 mg/kg/day) was applied for one week. Results: Liver and heart tissues were collected to evaluate 8-hydroxy-2 deoxyguanosine (8-OHdG), caspase-8 and caspase-9 levels. Hypothyroidism caused DNA damage in the liver, while hyperthyroidism caused DNA damage in the heart tissue. Hyperthyroidism also led to a significant increase in levels of caspase-8 and caspase-9 in liver tissue. Conclusions: The results of the study show that DNA damage and caspase levels in the heart and liver are affected differently in experimental hypothyroidism and hyperthyroidism.
Yazarlar (6)
1
Rasim Mogulkoc
2
Gulnur Guler
3
Dervis Dasdelen
4
Saltuk Bugra Baltaci
5
Abdulkerim Kasim Baltaci
6
Abdullah Sivrikaya
Anahtar Kelimeler
apoptosis
DNA damage
heart
hyperthyroidism
hypothyroidism
liver
rat
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
6
Yazar
7
Anahtar Kelime