Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin
Biological Trace Element Research · Temmuz 2023
YÖKSİS Kayıtları
Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin
Biological Trace Element Research · 2022 SCI-Expanded
Prof. Dr. HALUK GÜMÜŞ →
Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin.
Biological trace element research · 2023 SSCI
Prof. Dr. RASİM MOĞULKOÇ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Investigation of the Relationship Between Serum Trace Elements and MSFC Levels in Multiple Sclerosis: A Cross-sectional Case-Control Study
2025 ISSN: 0163-4984 SCI
Dr. Öğr. Üyesi CİHAT ÖZGÜNCÜ →
Effects of Zinc Deficiency and Supplementation on Malondialdehyde and Glutathione Levels in Blood and Tissues of Rats Performing Swimming Exercise
2003 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Effect of Selenium Supplementation on Lipid Peroxidation Antioxidant Enzymes and Lactate Levels in Rats Immediately After Acute Swimming Exercise
2011 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Effects of dietary cadmium and boron supplementation on performance eggshell quality and mineral concentrations of bone in laying hens
2015 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. OSMAN OLGUN →
Serum and Cerebrospinal Fluid Magnesium Levels Glasgow Coma Scores and In Hospital Mortality in Patients with Acute Stroke
2009 ISSN: 0163-4984 SCI
Prof. Dr. HASAN KARA →
Magnesium Sulfate in Emergency Department Patients with Hypertension
2009 ISSN: 0163-4984 SCI
Prof. Dr. HASAN KARA →
Levels of Selenium Zinc Copper and Cardiac Troponin I in Serum of Patients with Acute Coronary Syndrome
2013 ISSN: 0163-4984 SSCI
Prof. Dr. HASAN KARA →
Elements in Sera of Elite Taekwondo Athletes Effects of Vitamin E Supplementation
2011 ISSN: 0163-4984 SCI 3 atıf
Prof. Dr. EKREM BOYALI →
The Effect of Vitamin A Supplementation on Various Elements in Elite Taekwondo Players
2011 ISSN: 0163-4984 SCI 2 atıf
Prof. Dr. EKREM BOYALI →
Effects of Exercise and Zinc Supplementation on Cytokine Release in Young Wrestlers
2011 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effect of Intraperitoneal Selenium Administration on Liver Glycogen Levels in Rats Subjected to Acute Forced Swimming
2011 ISSN: 0163-4984 SSCI
Prof. Dr. MEHMET KILIÇ →
Effects of Acute Swimming Exercise on Some Elements in Rats
2009 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers
2010 ISSN: 0163-4984 SCI-Expanded
Prof. Dr. MEHMET KILIÇ →
Effects of Chronic Fluorosis on Electrocardiogram in Sheep
2003 ISSN: 0163-4984 SCI-Expanded 24 atıf
Prof. Dr. NURCAN DÖNMEZ →
Effect of Zinc Supplementation on Antioxidant Activity in Young Wrestlers
2010 ISSN: 0163-4984 SCI-Expanded 10 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Testosterone Levels in Athletes at Rest and Exhaustion Effects of Calcium Supplementation
2009 ISSN: 0163-4984 SCI-Expanded 3 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of Magnesium Supplementation on Testosterone Levels of Athletes and Sedentary Subjects at Rest and after Exhaustion
2011 ISSN: 0163-4984 SCI-Expanded 6 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissue of rats performing swimming exercise
2003 ISSN: 0163-4984 SCI-Expanded 18 atıf
Prof. Dr. ABDULKERİM KASIM BALTACI →
Effects of exercise and zinc supplementation on cytokine release in young wrestlers
2011 ISSN: 0163-4984 SSCI 4 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Effects of zinc supplementation on the element distribution in kidney tissue of diabetic rats subjected to acute swimming
2012 ISSN: 0163-4984 SSCI 5 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Makale Bilgileri
ISSN01634984
Yayın TarihiTemmuz 2023
Cilt / Sayfa201 · 3381-3386
Scopus ID2-s2.0-85137435219
Özet
Metabolic dysfunction is a critical step in the etiopathogenesis of Alzheimer’s disease. In this progressive neurological disorder, impaired zinc homeostasis has a key role that needs to be clarified. The aim of this study was to investigate the effect of zinc deficiency and administration on hippocampal Nogo-A receptor and osteocalcin gene expression in rats injected with intracerebroventricular streptozotocin (icv-STZ). Forty male Wistar rats were divided into 5 groups in equal numbers: Sham 1 group received icv artificial cerebrospinal fluid (aCSF); Sham 2 group received icv a CSF and i.p. saline; STZ group received 3 mg/kg icv STZ; STZ-Zn-deficient group received 3 mg/kg icv STZ and fed a zinc-deprived diet; STZ-Zn-supplemented group received 3 mg/kg icv STZ and i.p. zinc sulfate (5 mg/kg/day). Hippocampus tissue samples were taken following the cervical dislocation of the animals under general anesthesia. Nogo-A receptor and osteocalcin gene expression levels were determined by real-time-PCR method. Zinc supplementation attenuated the increase in hippocampal Nogo-A receptor gene expression, which was significantly increased in zinc deficiency. Again, zinc supplementation upregulated the intrinsic protective mechanisms of the brain by activating osteocalcin-expressing cells in the brain. The results of the study show that zinc has critical effects on Nogo-A receptor gene expression and hippocampal osteocalcin gene expression levels in the memory-sensitive rat hippocampus that is impaired by icv-STZ injection. These results are the first to examine the effect of zinc deficiency and supplementation on hippocampal Nogo-A receptor and osteocalcin gene expression in icv-STZ injection in rats.
Yazarlar (6)
1
Haluk Gümüş
2
Saltuk Bugra Baltaci
3
Omer Unal
4
Elif Gulbahce-Mutlu
5
Rasim Mogulkoc
6
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
Hippocampus
Icv-STZ injection
Nogo-A receptor
Osteocalcin
Zinc
Kurumlar
Karatay Üniversitesi
Konya Turkey
Kirikkale Üniversitesi
Kirikkale Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Biological Trace Element Research
Q1
OA
SJR Skoru0,890
H-Index119
YayıncıSpringer
ÜlkeUnited States
Inorganic Chemistry (Q1)
Biochemistry (Q2)
Biochemistry (medical) (Q2)
Clinical Biochemistry (Q2)
Endocrinology, Diabetes and Metabolism (Q2)
Medicine (miscellaneous) (Q2)
Metrikler
10
Atıf
6
Yazar
5
Anahtar Kelime