Scopus
YÖKSİS Eşleşti
Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin
Biological Trace Element Research · Temmuz 2023
YÖKSİS Kayıtları
Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin
Biological Trace Element Research · 2022 SCI-Expanded
PROFESÖR HALUK GÜMÜŞ →
Zinc Ameliorates Nogo-A Receptor and Osteocalcin Gene Expression in Memory-Sensitive Rat Hippocampus Impaired by Intracerebroventricular Injection of Streptozotocin.
Biological trace element research · 2023 SSCI
PROFESÖR RASİM MOĞULKOÇ →
Makale Bilgileri
DergiBiological Trace Element Research
Yayın TarihiTemmuz 2023
Cilt / Sayfa201 · 3381-3386
Scopus ID2-s2.0-85137435219
Özet
Metabolic dysfunction is a critical step in the etiopathogenesis of Alzheimer’s disease. In this progressive neurological disorder, impaired zinc homeostasis has a key role that needs to be clarified. The aim of this study was to investigate the effect of zinc deficiency and administration on hippocampal Nogo-A receptor and osteocalcin gene expression in rats injected with intracerebroventricular streptozotocin (icv-STZ). Forty male Wistar rats were divided into 5 groups in equal numbers: Sham 1 group received icv artificial cerebrospinal fluid (aCSF); Sham 2 group received icv a CSF and i.p. saline; STZ group received 3 mg/kg icv STZ; STZ-Zn-deficient group received 3 mg/kg icv STZ and fed a zinc-deprived diet; STZ-Zn-supplemented group received 3 mg/kg icv STZ and i.p. zinc sulfate (5 mg/kg/day). Hippocampus tissue samples were taken following the cervical dislocation of the animals under general anesthesia. Nogo-A receptor and osteocalcin gene expression levels were determined by real-time-PCR method. Zinc supplementation attenuated the increase in hippocampal Nogo-A receptor gene expression, which was significantly increased in zinc deficiency. Again, zinc supplementation upregulated the intrinsic protective mechanisms of the brain by activating osteocalcin-expressing cells in the brain. The results of the study show that zinc has critical effects on Nogo-A receptor gene expression and hippocampal osteocalcin gene expression levels in the memory-sensitive rat hippocampus that is impaired by icv-STZ injection. These results are the first to examine the effect of zinc deficiency and supplementation on hippocampal Nogo-A receptor and osteocalcin gene expression in icv-STZ injection in rats.
Yazarlar (6)
1
Haluk Gümüş
2
Saltuk Bugra Baltaci
3
Omer Unal
4
Elif Gulbahce-Mutlu
5
Rasim Mogulkoc
6
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
Hippocampus
Icv-STZ injection
Nogo-A receptor
Osteocalcin
Zinc
Kurumlar
Karatay Üniversitesi
Konya Turkey
Kirikkale Üniversitesi
Kirikkale Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
6
Yazar
5
Anahtar Kelime