Scopus
YÖKSİS Eşleşti
The impact of flavonoids and BDNF on neurogenic process in various physiological/pathological conditions including ischemic insults: a narrative review
Nutritional Neuroscience · Ocak 2024
YÖKSİS Kayıtları
The impact of flavonoids and BDNF on neurogenic process in various physiological/pathological conditions including ischemic insults: a narrative review
Nutritional Neuroscience · 2024 SCI
PROFESÖR RASİM MOĞULKOÇ →
The impact of flavonoids and BDNF on neurogenic process in various
physiological/pathological conditions including ischemic insults: a narrative review
Journal of Nutritional Science · 2024 SCI-Expanded
PROFESÖR ABDULKERİM KASIM BALTACI →
Makale Bilgileri
DergiNutritional Neuroscience
Yayın TarihiOcak 2024
Cilt / Sayfa27 · 1025-1041
Scopus ID2-s2.0-85180898108
Özet
Objective: Ischemic stroke is the leading cause of mortality and disability worldwide with more than half of survivors living with serious neurological sequelae thus, it has recently attracted considerable attention in the field of medical research. Neurogenesis is the process of formation of new neurons in the brain, including the human brain, from neural stem/progenitor cells [NS/PCs] which reside in neurogenic niches that contain the necessary substances for NS/PC proliferation, differentiation, migration, and maturation into functioning neurons which can integrate into a pre-existing neural network. Neurogenesis can be modulated by many exogenous and endogenous factors, pathological conditions. Both brain-derived neurotrophic factor, and flavonoids can modulate the neurogenic process in physiological conditions and after various pathological conditions including ischemic insults. Aim: This review aims to discuss neurogenesis after ischemic insults and to determine the role of flavonoids and BDNF on neurogenesis under physiological and pathological conditions with a concentration on ischemic insults to the brain in particular. Method: Relevant articles assessing the impact of flavonoids and BDNF on neurogenic processes in various physiological/pathological conditions including ischemic insults within the timeline of 1965 until 2023 were searched using the PubMed database. Conclusions: The selected studies have shown that ischemic insults to the brain induce NS/PC proliferation, differentiation, migration, and maturation into functioning neurons integrating into a pre-existing neural network. Flavonoids and BDNF can modulate neurogenesis in the brain in various physiological/pathological conditions including ischemic insults. In conclusion, flavonoids and BDNF may be involved in post-ischemic brain repair processes through enhancing endogenous neurogenesis.
Yazarlar (4)
1
Esen Yilmaz
2
Saltuk Bugra Baltaci
3
Rasim Mogulkoc
4
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
BDNF
flavonoid
granule cell
hippocampus
ischemia-reperfusion
ischemic insult
neurogenesis
stroke
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey