Scopus
YÖKSİS Eşleşti
Apoptosis of hippocampus and cerebellum induced with brain ischemia reperfusion prevented by 3’,4’-dihydroxyflavonol (DiOHF)
Biotechnic and Histochemistry · Ocak 2024
YÖKSİS Kayıtları
Apoptosis of hippocampus and cerebellum induced with brain ischemia reperfusion prevented by 3’,4’-dihydroxyflavonol (DiOHF)
Biotechnic & Histochemistry · 2024 SCI
PROFESÖR ENDER ERDOĞAN →
Apoptosis of hippocampus and cerebellum induced with brain ischemia reperfusion prevented by 3’,4’-dihydroxyflavonol (DiOHF)
Biotechnic & Histochemistry · 2024 Art Index (Art Research Database, EBSCO)
PROFESÖR RASİM MOĞULKOÇ →
Makale Bilgileri
DergiBiotechnic and Histochemistry
Yayın TarihiOcak 2024
Scopus ID2-s2.0-85197464755
Özet
The present study aimed to determine the effect of 3',4'-dihydroxyflavonol (DiOHF) on apoptosis in the cerebellum and hippocampus in rats with ischemia-reperfusion. A total of 38 Wistar albino male rats were used. Experimental groups were designed as Group 1-Sham; Group 2-Ischemia-reperfusion (IR), in which animals were anesthetized and carotid arteries ligated for 30 minutes (ischemia) and reperfused 30 minutes; Group 3- IR + DiOHF (10 mg/kg); Group 4- Ischemia + DiOHF (10 mg/kg) + reperfusion; Group 5-DiOHF + IR. DiOHF was supplemented as 10 mg/kg by intraperitoneal injection 30 minutes before IR. Following application, the animals were sacrificed under general anesthetic by cervical dislocation, and the cerebellum and hippocampus tissues were analyzed for apoptosis. IR significantly increased hippocampus and cerebellum apoptosis activity, confirmed by Hematoxylin-Eosin, TUNEL labeling, and Caspase-8 activity. However, these values were significantly suppressed by the administration of DiOHF, especially when used before the ischemia and reperfusion. The results of the study show that increased apoptosis in the cerebellum and hippocampus tissue was inhibited by intraperitoneal DiOHF supplementation.
Yazarlar (5)
1
Dervis Dasdelen
2
Merve Solmaz
3
Rasim Mogulkoc
4
Abdulkerim Kasim Baltaci
5
Ender Erdoğan
Anahtar Kelimeler
3',4'-dihydroxyflavonol
brain IR
caspase-8
cerebellum
hippocampus
rat
TUNEL
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey