Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Nicotinamide n-methyltransferase expression and its association with phospho-akt, p53 expression, and survival in high-grade endometrial cancer
Turkish Journal of Medical Sciences · Ocak 2019
YÖKSİS Kayıtları
Nicotinamide N-methyltransferase Expression and its Association with Phospho-Akt, p53 Expression and Survival in High Grade Endometrial Cancer
TURKISH JOURNAL OF MEDICAL SCIENCES · 2019 SCI-Expanded
Prof. Dr. NEVZAT SERDAR UĞRAŞ →
Nicotinamide N-methyltransferase Expression and its Association with Phospho-Akt, p53 Expression and Survival in High Grade Endometrial Cancer
TURKISH JOURNAL OF MEDICAL SCIENCES · 2019 SCI-Expanded
Prof. Dr. ÇETİN ÇELİK →
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer
Turkish Journal Of Medical Sciences · 2019 TR DİZİN
Prof. Dr. ÇETİN ÇELİK →
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer
Turkish Journal Of Medical Sciences · 2019 TR DİZİN
Doç. Dr. İSMAİL HARMANKAYA →
Nicotinamide N-methyltransferase expression and its association with phospho-Akt, p53 expression, and survival in high-grade endometrial cancer
Turkish Journal Of Medical Sciences · 2020 SCI-Expanded
Prof. Dr. NEVZAT SERDAR UĞRAŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of 48 week response of treatment naive chronic hepatitis B patients to 0 5 mg day entecavir
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. ŞUA SÜMER →
Serum Interleukin 8 Levels May Predict Relapse In Brucellosis
2012 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Evaluation of 48 week Response of Treatment Naive Chronic Hepatitis B Patients to 0 5 mg day Entecavir
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
The efficacy of intermittant low dose systemic corticosteroid in the treatment of alopecia areata
2004 ISSN: 1300-0144 SCI-Expanded 1 atıf
Prof. Dr. GÜLCAN SAYLAM KURTİPEK →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. HASAN KARA →
Analysis of periprocedural medical complications during carotid angioplasty and stent placement
2010 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
High risk febrile neutropenia and its management in childrenwith solid tumors and lymphoma
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. YAVUZ KÖKSAL →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. MUAZ BELVİRANLI →
Effectiveness of pelvic floor muscle training on symptoms and uroflowmetryparameters in female patients with overactive bladder
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. EVRİM ÇAKMAKÇI →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. NİLSEL OKUDAN →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Refeeding hypophosphatemia a potentially fatal danger in the intensive care unit
2014 ISSN: 13000144 SCI-Expanded
Prof. Dr. SÜLEYMAN BALDANE →
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. BANU BOZKURT →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. AYŞEGÜL BAYIR →
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
2014 ISSN: 13000144 SCI-Expanded
Prof. Dr. METE KAAN BOZKURT →
Hypo and hypervolemic edema in children with steroid sensitive nephrotic syndrome
2015 ISSN: 13000144 SCI-Expanded Q3
Dr. Öğr. Üyesi MEHMET AKİF BÜYÜKAVCI →
Evaluation of dental technician’s pneumoconiosis using chest X-rayand HRCT: correlation between radiological and functional findings
2017 ISSN: 13000144 SCI-Expanded
Prof. Dr. RECAİ ERGÜN →
Cytokeratin 18 and h FABP levels in intestinal ischemia reperfusioninjury role of coenzyme Q10
2013 ISSN: 1300-0144 SSCI 2 atıf
Prof. Dr. NİLSEL OKUDAN →
N terminal pro brain natriuretic peptide levels in children with allergic rhinitis
2016 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Makale Bilgileri
ISSN13000144
Yayın TarihiOcak 2019
Cilt / Sayfa49 · 1547-1554
Scopus ID2-s2.0-85074163044
Erişim🔓 Açık Erişim
Özet
Background/aim: Nicotinamide N-methyltransferase (NNMT) is an enzyme that is overexpressed in malignancies. NNMT expression has not been previously studied in endometrial cancer (EC). Increased phospho-Akt (pAkt) levels in response to NNMT overexpression have been reported in in vitro studies of different cancer types. We assayed NNMT expression in primary and metastatic high-grade EC and investigated the relationship of NNMT with p53, pAkt, and survival. Materials and methods: NNMT, pAkt, and p53 expressions were assayed in 100 tissue samples of benign endometria, primary EC, and metastatic EC by immunohistochemistry. Results: The NNMT immunoreactivity score was significantly higher in primary high-grade EC than benign endometrial tissue (P = 0.001). NNMT expression in metastatic tissue was significantly higher than in primary cancer (P < 0.001). Metastatic stromal NNMT expression was significantly higher than that of the adjacent tumor and stroma adjacent to the primary tumor. p53 expression in the primary tumor showed a significant positive correlation with omental NNMT and pAkt expression. NNMT expression was also correlated with pAkt expression in metastatic tissue. NNMT overexpression in metastatic tissue was associated with decreased survival (P = 0.039). Conclusion: This study suggests that NNMT may promote cancer progression and that NNMT overexpression is associated with aberrant p53 expression, pAkt, and poor survival. NNMT’s role in cancer progression could make it a target of EC therapy.
Yazarlar (4)
1
Serra Akar
ORCID: 0000-0002-0466-140X
2
İsmail Harmankaya
3
Serdar Uğraş
4
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
Akt
Disease-specific survival
Nicotinamide N-methyltransferase
P53
Type II endometrial cancer
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Medical Sciences
Q3
SJR Skoru0,386
H-Index44
YayıncıTUBITAK
ÜlkeTurkey
Medicine (miscellaneous) (Q3)
Metrikler
15
Atıf
4
Yazar
5
Anahtar Kelime