Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Cytotoxic effect of Conyza canadensis (L.) cronquist on human lung cancer cell lines
Turkish Journal of Pharmaceutical Sciences · Aralık 2016
YÖKSİS Kayıtları
Cytotoxic Effect of Conyza canadensis (L.) Cronquist on Human Lung Cancer Cell Lines
Turkish Journal of Pharmaceutical Sciences · 2016 Web of Science ESCI, Scopus SJR, Embase, Ebsco
DOÇENT FATMA AYAZ →
Makale Bilgileri
DergiTurkish Journal of Pharmaceutical Sciences
Yayın TarihiAralık 2016
Cilt / Sayfa13 · 342-346
Scopus ID2-s2.0-85012131941
Erişim🔓 Açık Erişim
Özet
Asteraceae family plants are receiving great attention because they have potential anticancer activity. Therefore, in this study, the cytotoxic effect of Conyza canadensis (L.) Cronquist (Asteraceae) were tested against human lung adenocarcinoma cell lines (A549 and H1299) for the first time. Cytotoxic effect of the n-hexane, chloroform, n-butanol and remaining water (R-H2O) extracts fractioned from the methanol extracts of the aerial parts and roots of C. canadensis was investigated using Sulforhodamine B (SRB) assay and percent (%) viability was measured. The results indicate that the extracts of C. canadensis have cytotoxic activities on these cells in a dose-dependent manner. The root extracts exhibited relatively higher cytotoxic effects than the aerial parts of the plant. The most active extract was found to be n-hexane extract of the roots with IC50 values 94.73 and 84.85 µg/mL on A549 and H1299 cell lines, respectively. These results suggest that C. canadensis exhibits moderate cytotoxic effect in lung cancer cells. This might be taken into account in its use for therapeutic purposes.
Yazarlar (4)
1
Fatma Ayaz
2
Mehmet Sarimahmut
3
Nurgün Küçükboyacı
4
Engin Ulukaya
Anahtar Kelimeler
Asteraceae
Conyza canadensis
Cytotoxic activity
Lung cancer
Sulforhodamine B assay
Kurumlar
Bursa Uludağ Üniversitesi
Bursa Turkey
Gazi Üniversitesi
Ankara Turkey
İstinye Üniversitesi
Istanbul Turkey
Metrikler
4
Atıf
4
Yazar
5
Anahtar Kelime